ERBB2IP Antibody – Rabbit Polyclonal

This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Erbin: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Belongs to the LAP (LRR and PDZ) protein family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 5q12.3

Cellular Component: basement membrane; basolateral plasma membrane; cell junction; cytoplasm; hemidesmosome; nucleoplasm; nucleus; plasma membrane

Molecular Function: ErbB-2 class receptor binding; integrin binding; protein binding; receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; inhibition of NF-kappaB transcription factor; response to lipopolysaccharide; response to muramyl dipeptide; signal transduction