ESR2 Antibody – Mouse Monoclonal

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]

ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 14q23.2

Cellular Component: cilium; extracellular region; mitochondrion; neuron projection; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; plasma membrane

Molecular Function: DNA binding; drug binding; enzyme binding; estrogen receptor activity; estrogen response element binding; ligand-dependent nuclear receptor activity; peroxisome proliferator activated receptor binding; protein binding; receptor antagonist activity; steroid binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity; zinc ion binding

Biological Process: amygdala development; behavioral fear response; cell-cell signaling; cerebellum development; estrogen receptor signaling pathway; hypothalamus development; learning and/or memory; negative regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; ovarian follicle development; positive regulation of apoptosis; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of vasodilation; prostate gland development; regulation of neuron apoptosis; regulation of transcription, DNA-dependent; response to activity; response to ethanol; response to genistein; response to insecticide; response to nutrient levels; response to testosterone stimulus; response to water deprivation; Sertoli cell development; Sertoli cell proliferation; signal transduction; transcription initiation from RNA polymerase II promoter