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ESRP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS769102

MBS769102 is an antibody targeting ESRP2. Also known as ESRP2 Rabbit Polyclonal. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ESRP2, Polyclonal Antibody
Full Product Name
ESRP2 Rabbit Polyclonal
Product Gene Name
anti-ESRP2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
77,364 Da
OMIM
612960
Immunogen
Epithelial splicing regulatory protein 2
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ESRP2 antibody
ELISA (EIA), Western Blot (WB)

Western Blot (WB) of anti-ESRP2 antibody

HeLa cells were subjected to SDS PAGE followed by western blot with MBS769102 (ESRP2 antibody) at dilution of 1:300
Rabbit Anti-ESRP2 Polyclonal Antibody – Cat# MBS769102

Other Notes

Small volumes of anti-ESRP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ESRP2. It may not necessarily be applicable to this product.

NCBI GI #
45935393
NCBI GeneID
80004
NCBI Accession #
NP_079215.2
UniProt Secondary Accession #
Q8N6H8; Q8WZ15; Q9H6I4
UniProt Related Accession #
Q9H6T0
GenBank Nucleotide #
NM_024939.2
NCBI Official Full Name
epithelial splicing regulatory protein 2
NCBI Official Synonym Full Names
epithelial splicing regulatory protein 2
NCBI Official Symbol
ESRP2
NCBI Official Synonym Symbols
RBM35B
UniProt Protein Name
Epithelial splicing regulatory protein 2
UniProt Synonym Protein Names
RNA-binding motif protein 35B; RNA-binding protein 35B
Protein Family
Epithelial splicing regulatory protein
UniProt Gene Name
ESRP2
UniProt Synonym Gene Names
RBM35B
UniProt Entry Name
ESRP2_HUMAN
NCBI Protein Information
epithelial splicing regulatory protein 2

NCBI Summary for ESRP2

ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

UniProt Comments for ESRP2

RBM35B: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Belongs to the ESRP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: mRNA binding; nucleotide binding

Biological Process: fibroblast growth factor receptor signaling pathway; mRNA processing; regulation of RNA splicing; RNA splicing
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Research Articles on ESRP2

1. Findings define a direct role for ESRP2 in the generation of conserved repertoires of adult splice isoforms that facilitate terminal differentiation and maturation of hepatocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ESRP2 antibody

 Products by Pathway  Pathway Diagram
 FGFR2 Alternative Splicing Pathway antibodies  FGFR2 Alternative Splicing Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By FGFR Pathway antibodies  Signaling By FGFR Pathway Diagram
 Signaling By FGFR2 Pathway antibodies  Signaling By FGFR2 Pathway Diagram

Diseases associated with anti-ESRP2 antibody

 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >3 publications with ESRP2 and Skin Diseases
 Breast Neoplasms Antibodies  >2 publications with ESRP2 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with ESRP2 and Carcinoma, Hepatocellular
 Brain Diseases Antibodies  >1 publications with ESRP2 and Brain Diseases
 Nervous System Diseases Antibodies  >1 publications with ESRP2 and Nervous System Diseases
 Lung Neoplasms Antibodies  >1 publications with ESRP2 and Lung Neoplasms
 Lung Diseases Antibodies  >1 publications with ESRP2 and Lung Diseases

Organs/Tissues associated with anti-ESRP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >3 publications with ESRP2 and Skin
 Lymph Node Antibodies  >2 publications with ESRP2 and Lymph Node
 Lymph Antibodies  >2 publications with ESRP2 and Lymph
 Prostate Antibodies  >1 publications with ESRP2 and Prostate
 Uterus Antibodies  >1 publications with ESRP2 and Uterus
 Placenta Antibodies  >1 publications with ESRP2 and Placenta
 Cervix Antibodies  >1 publications with ESRP2 and Cervix
 Liver Antibodies  >1 publications with ESRP2 and Liver
 Uncharacterized Tissue Antibodies  >1 publications with ESRP2 and Uncharacterized Tissue
 Nerve Antibodies  >1 publications with ESRP2 and Nerve
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