EVI1 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

MDS1: A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1. 6 isoforms of the human protein are produced by alternative promoter.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 3q26.2

Cellular Component: cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; intracellular membrane-bound organelle; nuclear speck; nucleoplasm; nucleus

Molecular Function: DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; protein binding; protein homodimerization activity; transcription factor activity

Biological Process: apoptosis; cell differentiation; negative regulation of JNK cascade; negative regulation of programmed cell death; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transcription, DNA-dependent; regulation of cell cycle; regulation of transcription, DNA-dependent; transcription, DNA-dependent