Ezrin (EZR) Antibody – Rabbit Polyclonal

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]

Ezrin: a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: actin cytoskeleton; actin filament; apical part of cell; apical plasma membrane; basolateral plasma membrane; brush border; cell projection; cortical cytoskeleton; cytoplasm; cytosol; endosome; extracellular space; extrinsic to membrane; filopodium; focal adhesion; immunological synapse; membrane; microvillus; microvillus membrane; myelin sheath; nucleolus; perinuclear region of cytoplasm; plasma membrane; ruffle; T-tubule; uropod; vesicle

Molecular Function: actin binding; actin filament binding; ATPase binding; cell adhesion molecule binding; microtubule binding; protein binding; protein domain specific binding

Biological Process: actin cytoskeleton reorganization; actin filament bundle formation; astral microtubule organization and biogenesis; axon guidance; cortical microtubule organization and biogenesis; cytoskeletal anchoring; D-glucose absorption; establishment of centrosome localization; establishment of epithelial cell polarity; filopodium formation; gland morphogenesis; leukocyte adhesion; membrane to membrane docking; microvillus biogenesis; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; phosphoinositide-mediated signaling; positive regulation of multicellular organism growth; positive regulation of protein secretion; receptor internalization; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; regulation of cell size; regulation of microvillus length