FBXW11 Antibody – Rabbit Polyclonal

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

FBW1B: a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex May participate in Wnt signaling. Three alternatively spliced isoforms have been described.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: centrosome; cytosol; nucleus; SCF ubiquitin ligase complex; ubiquitin ligase complex

Molecular Function: protein binding; protein dimerization activity; ubiquitin-protein ligase activity

Biological Process: G2/M transition of mitotic cell cycle; negative regulation of NF-kappaB import into nucleus; negative regulation of transcription, DNA-dependent; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid dephosphorylation; protein destabilization; protein polyubiquitination; protein ubiquitination; rhythmic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; Wnt receptor signaling pathway