FGF18 Antibody – Mouse Monoclonal

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]

FGF18: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. Belongs to the heparin-binding growth factors family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: extracellular region; extracellular space; nucleolus

Molecular Function: 1-phosphatidylinositol-3-kinase activity; growth factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding

Biological Process: anatomical structure morphogenesis; angiogenesis; cell-cell signaling; chondrocyte development; endochondral ossification; fibroblast growth factor receptor signaling pathway; intramembranous ossification; lung development; MAPKKK cascade; peptidyl-tyrosine phosphorylation; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of chondrocyte differentiation; positive regulation of GTPase activity; positive regulation of MAP kinase activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of endothelial cell proliferation; regulation of phosphoinositide 3-kinase cascade; signal transduction