FRZB Antibody – Rabbit Polyclonal

FRZB: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Defects in FRZB are associated with susceptibility to osteoarthritis type 1(OS1). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: extracellular space; integral to membrane; membrane

Molecular Function: G-protein coupled receptor activity; Wnt receptor activity; Wnt-protein binding

Biological Process: convergent extension involved in organogenesis; G-protein coupled receptor protein signaling pathway; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of Wnt receptor signaling pathway; neural crest cell differentiation; positive regulation of apoptosis; positive regulation of fat cell differentiation; skeletal development

Disease: Osteoarthritis Susceptibility 1