GAL3ST1 Antibody – Rabbit Polyclonal

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GAL3ST1: Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). Belongs to the galactose-3-O-sulfotransferase family.

Protein type: Membrane protein, integral; EC 2.8.2.11; Lipid Metabolism - sphingolipid; Transferase

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: Golgi membrane; integral to plasma membrane; membrane

Molecular Function: galactosylceramide sulfotransferase activity; sulfotransferase activity

Biological Process: galactosylceramide biosynthetic process; myelination; protein amino acid N-linked glycosylation; spermatogenesis