Galectin-1 (LGALS1) Antibody – Mouse Monoclonal

galectin-1: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N- acetyllactosamine). Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion. Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.

Protein type: Extracellular matrix; Secreted; Cell adhesion

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cell surface; cytoplasm; extracellular matrix; extracellular space; intracellular; nucleus; proteinaceous extracellular matrix

Molecular Function: glycoprotein binding; lactose binding; laminin binding; protein binding; protein homodimerization activity; signal transducer activity

Biological Process: apoptosis; multicellular organismal response to stress; myoblast differentiation; plasma cell differentiation; positive regulation of erythrocyte aggregation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of virion penetration into host cell; regulation of apoptosis; response to axon injury; response to drug; signal transduction; T cell costimulation