GATA6 Antibody – Rabbit Polyclonal

This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]

GATA6: Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 18q11.1-q11.2

Cellular Component: nucleoplasm; nucleus; transcription factor complex

Molecular Function: chromatin binding; protein binding; protein kinase binding; RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity; transcription factor binding; zinc ion binding

Biological Process: blood coagulation; cardiac muscle cell differentiation; cardiac muscle hypertrophy; cell development; cell fate commitment; cellular protein metabolic process; endodermal cell fate determination; in utero embryonic development; liver development; male gonad development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; organ formation; phospholipid metabolic process; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cardioblast differentiation; positive regulation of transcription from RNA polymerase II promoter; response to drug; response to estrogen stimulus; smooth muscle cell differentiation; transcription from RNA polymerase II promoter; tube morphogenesis

Disease: Atrial Septal Defect 9; Atrioventricular Septal Defect 5; Conotruncal Heart Malformations; Heart Defects, Congenital, And Other Congenital Anomalies; Tetralogy Of Fallot