GCNT2 Antibody – Rabbit Polyclonal

This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GCNT2: Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C. Belongs to the glycosyltransferase 14 family. 3 isoforms of the human protein are produced by alternative splicing

Protein type: EC 2.4.1.150

Chromosomal Location of Human Ortholog: 6p24.2

Cellular Component: Golgi membrane; integral to membrane; membrane

Molecular Function: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity

Biological Process: glycosaminoglycan biosynthetic process; multicellular organismal development; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of heterotypic cell-cell adhesion; positive regulation of protein kinase B signaling cascade; protein amino acid glycosylation; transforming growth factor beta receptor signaling pathway

Disease: Blood Group, I System