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GGPS1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS769677

MBS769677 is an antibody targeting GGPS1. Also known as GGPS1 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GGPS1, Polyclonal Antibody
Full Product Name
GGPS1 Rabbit Polyclonal
Product Gene Name
anti-GGPS1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
28,423 Da
OMIM
606982
Immunogen
Geranylgeranyl diphosphate synthase 1
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-GGPS1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Immunohistochemistry (IHC) of anti-GGPS1 antibody

Immunohistochemistry of paraffin-embedded human kidney using MBS769677 (GGPS1 antibody) at dilution of 1:100
Rabbit Anti-GGPS1 Polyclonal Antibody – Cat# MBS769677

Western Blot (WB) of anti-GGPS1 antibody

mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS769677 (GGPS1 antibody) at dilution of 1:500
Rabbit Anti-GGPS1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS769677

Other Notes

Small volumes of anti-GGPS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GGPS1. It may not necessarily be applicable to this product.

NCBI GI #
83700220
NCBI GeneID
9453
NCBI Accession #
NP_001032354.1
UniProt Secondary Accession #
Q5T2C8; Q6NW19; A8MVQ8
UniProt Related Accession #
O95749
GenBank Nucleotide #
NM_001037277.1
NCBI Official Full Name
geranylgeranyl pyrophosphate synthase
NCBI Official Synonym Full Names
geranylgeranyl diphosphate synthase 1
NCBI Official Symbol
GGPS1
NCBI Official Synonym Symbols
GGPPS; GGPPS1
UniProt Protein Name
Geranylgeranyl pyrophosphate synthase
UniProt Synonym Protein Names
(2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase (EC:2.5.1.1); Farnesyl diphosphate synthase; Farnesyltranstransferase (EC:2.5.1.29); Geranylgeranyl diphosphate synthase; Geranyltranstransferase (EC:2.5.1.10)
Protein Family
Heterodimeric geranylgeranyl pyrophosphate synthase
UniProt Gene Name
GGPS1
UniProt Synonym Gene Names
GGPP synthase; GGPPSase
UniProt Entry Name
GGPPS_HUMAN
NCBI Protein Information
geranylgeranyl pyrophosphate synthase

NCBI Summary for GGPS1

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
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UniProt Comments for GGPS1

GGPS1: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Belongs to the FPP/GGPP synthase family.

Protein type: EC 2.5.1.10; Motility/polarity/chemotaxis; Transferase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.1; EC 2.5.1.29

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: cytosol

Molecular Function: dimethylallyltranstransferase activity; farnesyltranstransferase activity; geranyltranstransferase activity; metal ion binding; protein binding

Biological Process: cholesterol biosynthetic process; farnesyl diphosphate biosynthetic process; geranyl diphosphate biosynthetic process; geranylgeranyl diphosphate biosynthetic process; isoprenoid metabolic process
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Research Articles on GGPS1

1. GGPPS1 may play a critical role during the development of HCC from cirrhosis and is of clinical significance for predicting biological character of HCC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GGPS1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway antibodies  Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway Diagram
 Terpenoid Backbone Biosynthesis Pathway antibodies  Terpenoid Backbone Biosynthesis Pathway Diagram
 Terpenoid Backbone Biosynthesis Pathway antibodies  Terpenoid Backbone Biosynthesis Pathway Diagram
 Geranylgeranyl Diphosphate Biosynthesis Pathway antibodies  Geranylgeranyl Diphosphate Biosynthesis Pathway Diagram
 Geranylgeranyldiphosphate Biosynthesis Pathway antibodies  Geranylgeranyldiphosphate Biosynthesis Pathway Diagram

Diseases associated with anti-GGPS1 antibody

 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >3 publications with GGPS1 and Insulin Resistance
 Skin Diseases Antibodies  >1 publications with GGPS1 and Skin Diseases
 Disease Models, Animal Antibodies  >1 publications with GGPS1 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >1 publications with GGPS1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with GGPS1 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with GGPS1 and Liver Diseases
 Fibrosis Antibodies  >1 publications with GGPS1 and Fibrosis
 Fatty Liver Antibodies  >1 publications with GGPS1 and Fatty Liver

Organs/Tissues associated with anti-GGPS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with GGPS1 and Liver
 Lung Antibodies  >3 publications with GGPS1 and Lung
 Adipose Tissue Antibodies  >2 publications with GGPS1 and Adipose Tissue
 Bone Antibodies  >1 publications with GGPS1 and Bone
 Muscle Antibodies  >1 publications with GGPS1 and Muscle
 Connective Tissue Antibodies  >1 publications with GGPS1 and Connective Tissue
 Blood Antibodies  >1 publications with GGPS1 and Blood
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