GNAI2 Antibody – Rabbit Polyclonal

The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

G-alpha i2: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, heterotrimeric alpha G((i/o/t/z)); G protein; G protein, heterotrimeric

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: centrosome; cytoplasm; cytosol; dendrite; heterotrimeric G-protein complex; lipid raft; membrane; midbody; nucleoplasm; plasma membrane

Molecular Function: G-protein beta/gamma-subunit binding; G-protein-coupled receptor binding; GTP binding; GTPase activity; metal ion binding; protein binding; signal transducer activity

Biological Process: acetylcholine receptor signaling, muscarinic pathway; activation of MAPKK activity; adenosine receptor signaling pathway; cell cycle; cell division; cell proliferation; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; gamma-aminobutyric acid signaling pathway; metabolic process; negative regulation of adenylate cyclase activity; negative regulation of synaptic transmission; positive regulation of cell proliferation; protein folding; regulation of calcium ion transport; response to nutrient; signal transduction

Disease: Ventricular Tachycardia, Familial