GNB5 Antibody – Rabbit Polyclonal

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]

G-beta 5: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the WD repeat G protein beta family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, heterotrimeric beta

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: cytosol; myelin sheath; nucleus; photoreceptor inner segment; photoreceptor outer segment; plasma membrane

Molecular Function: chaperone binding; G-protein gamma-subunit binding; GTPase activator activity; GTPase activity; protein binding; signal transducer activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity; protein folding; signal transduction