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GOSR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS769797

MBS769797 is an antibody targeting GOSR2. Also known as GOSR2/Membrin Rabbit Polyclonal. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GOSR2/Membrin, Polyclonal Antibody
Full Product Name
GOSR2/Membrin Rabbit Polyclonal
Product Gene Name
anti-GOSR2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
22,725 Da
OMIM
604027
Immunogen
Golgi SNAP receptor complex member 2
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-GOSR2 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

Western Blot (WB) of anti-GOSR2 antibody

JurKat cells were subjected to SDS PAGE followed by western blot with MBS769797 (GOSR2/Membrin antibody) at dilution of 1:1000
Rabbit Anti-GOSR2 Polyclonal Antibody – Cat# MBS769797

Other Notes

Small volumes of anti-GOSR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GOSR2. It may not necessarily be applicable to this product.

NCBI GI #
60499013
NCBI GeneID
9570
NCBI Accession #
NP_001012529.1
UniProt Secondary Accession #
Q8N4B8; Q96DA5; Q9BZZ4; D3DXJ5; D3DXJ6
UniProt Related Accession #
O14653
GenBank Nucleotide #
NM_001012511.2
NCBI Official Full Name
Golgi SNAP receptor complex member 2 isoform C
NCBI Official Synonym Full Names
golgi SNAP receptor complex member 2
NCBI Official Symbol
GOSR2
NCBI Official Synonym Symbols
Bos1; EPM6; GS27
UniProt Protein Name
Golgi SNAP receptor complex member 2
UniProt Synonym Protein Names
27 kDa Golgi SNARE protein; Membrin
Protein Family
Golgi SNAP receptor complex
UniProt Gene Name
GOSR2
UniProt Synonym Gene Names
GS27
UniProt Entry Name
GOSR2_HUMAN
NCBI Protein Information
Golgi SNAP receptor complex member 2

NCBI Summary for GOSR2

This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. [provided by RefSeq, Mar 2016]

UniProt Comments for GOSR2

GOSR2: Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network. Defects in GOSR2 are the cause of progressive myoclonic epilepsy type 6 (EPM6). A neurologic disorder characterized by onset of ataxia in the first years of life, followed by action myoclonus and seizures later in childhood, and loss of independent ambulation in the second decade. Cognition is not usually affected, although mild memory difficulties may occur in the third decade. Belongs to the GOSR2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytosol; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; integral to membrane; late endosome membrane; membrane; SNARE complex

Molecular Function: protein binding; SNAP receptor activity; SNARE binding; transporter activity

Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; Golgi to vacuole transport; intra-Golgi vesicle-mediated transport; protein targeting to vacuole; retrograde transport, endosome to Golgi; vesicle fusion with Golgi apparatus

Disease: Epilepsy, Progressive Myoclonic 6
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Research Articles on GOSR2

1. Based on the presented phenotype, we would advise movement disorder specialists to consider mutation analysis of GOSR2 in patients with Ramsay Hunt syndrome, especially when they also have areflexia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GOSR2 antibody

 Products by Pathway  Pathway Diagram
 Arf1 Pathway antibodies  Arf1 Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 COPI-mediated Anterograde Transport Pathway antibodies  COPI-mediated Anterograde Transport Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
 Cargo Concentration In The ER Pathway antibodies  Cargo Concentration In The ER Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram
 IRE1alpha Activates Chaperones Pathway antibodies  IRE1alpha Activates Chaperones Pathway Diagram
 Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway antibodies  Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway Diagram
 Intra-Golgi Traffic Pathway antibodies  Intra-Golgi Traffic Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram

Diseases associated with anti-GOSR2 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >6 publications with GOSR2 and Cardiovascular Diseases
 Hypertension Antibodies  >5 publications with GOSR2 and Hypertension
 Disease Models, Animal Antibodies  >3 publications with GOSR2 and Disease Models, Animal
 Seizures Antibodies  >3 publications with GOSR2 and Seizures
 Heart Diseases Antibodies  >3 publications with GOSR2 and Heart Diseases
 Congenital Abnormalities Antibodies  >2 publications with GOSR2 and Congenital Abnormalities
 Kidney Diseases Antibodies  >1 publications with GOSR2 and Kidney Diseases

Organs/Tissues associated with anti-GOSR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with GOSR2 and Blood
 Heart Antibodies  >4 publications with GOSR2 and Heart
 Kidney Antibodies  >2 publications with GOSR2 and Kidney
 Lung Antibodies  >2 publications with GOSR2 and Lung
 Brain Antibodies  >2 publications with GOSR2 and Brain
 Vascular Antibodies  >1 publications with GOSR2 and Vascular
 Thymus Antibodies  >1 publications with GOSR2 and Thymus
 Liver Antibodies  >1 publications with GOSR2 and Liver
 Eye Antibodies  >1 publications with GOSR2 and Eye
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