GPSM2 Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GPSM2: Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2. Ubiquitously expressed. Belongs to the GPSM family.

Protein type: G protein regulator, misc.

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: apical part of cell; cell cortex; cytoplasm

Molecular Function: G-protein alpha-subunit binding; GDP-dissociation inhibitor activity; identical protein binding; nucleotide binding; protein binding

Biological Process: establishment of mitotic spindle orientation; G-protein coupled receptor protein signaling pathway; maintenance of centrosome localization; mitotic spindle organization and biogenesis; regulation of catalytic activity

Disease: Chudley-mccullough Syndrome