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GRP94 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS769897

MBS769897 is an antibody targeting GRP94. Also known as GRP94 Mouse Monoclonal. Reactive in Human. Host: Mouse. More details

$360 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GRP94, Monoclonal Antibody
Full Product Name
GRP94 Mouse Monoclonal
Product Gene Name
anti-GRP94 antibody
Product Synonym Names
ECGP, GP96, GRP 94, GRP94, HSP90B1, TRA1, Tumor rejection antigen 1
Clonality
Monoclonal
Isotype
IgG2a
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3
Purity/Purification
Protein A+G purification; >= 95% as determined by SDS-PAGE
Preparation and Storage
Store at -20°C. (Avoid repeated freeze / thaw cycles.)
Molecular Weight
94 kDa
3D Structure
ModBase 3D Structure for P14625
Immunogen
Heat shock protein 90kDa beta (Grp94), member 1
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-GRP94 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-GRP94 antibody
WB: 1:500-1:3000
IHC: 1:50-1:500
IF: 1:50-1:200

Immunohistochemistry (IHC) of anti-GRP94 antibody

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using MBS769897 (GRP94 Antibody) at dilution of 1:200
Mouse Anti-GRP94 Monoclonal Antibody – Cat# MBS769897

Immunofluorescence (IF) of anti-GRP94 antibody

Immunofluorescent analysis of Hela cells using MBS769897 (GRP94 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Mouse IgG
Mouse Anti-GRP94 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS769897

Western Blot (WB) of anti-GRP94 antibody

human heart tissue were subjected to SDS PAGE followed by western blot with MBS769897 (GRP94 antibody) at dilution of 1:1000
Mouse Anti-GRP94 Monoclonal Antibody, Western Blot (WB) – Cat# MBS769897

Other Notes

Small volumes of anti-GRP94 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GRP94. It may not necessarily be applicable to this product.

NCBI GI #
403497
NCBI GeneID
404019
NCBI Accession #
AAA17708.1
UniProt Primary Accession #
P14625
UniProt Related Accession #
P41148
NCBI Official Full Name
GRP94
NCBI Official Symbol
HSP90B1
NCBI Official Synonym Symbols
TRA1; GRP94
UniProt Protein Name
Endoplasmin
UniProt Synonym Protein Names
94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1
Protein Family
Putative tetratricopeptide repeat protein
UniProt Gene Name
HSP90B1
UniProt Synonym Gene Names
GRP94; TRA1; GRP-94
UniProt Entry Name
ENPL_CANLF
NCBI Protein Information
endoplasmin

UniProt Comments for GRP94

GRP94: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9. Interacts with CNPY3. This interaction is disrupted in the presence of ATP. Interacts with TLR4 and TLR9, but not with TLR3. Belongs to the heat shock protein 90 family.

Protein type: Secreted; Heat shock protein; Apoptosis; Secreted, signal peptide

Cellular Component: endoplasmic reticulum lumen; melanosome; sarcoplasmic reticulum

Molecular Function: ATP binding; unfolded protein binding

Biological Process: ER-associated protein catabolic process; protein folding
Show more

Research Articles on GRP94

1. Increased HSP90 expression in canine PCs suggests the involvement of this molecule in carcinogenesis and tumour progression, supporting HSP90 as a potential target for therapeutic intervention.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GRP94 antibody

 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram

Diseases associated with anti-GRP94 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with GRP94 and Inflammation
 Liver Diseases Antibodies  >4 publications with GRP94 and Liver Diseases
 Disease Models, Animal Antibodies  >4 publications with GRP94 and Disease Models, Animal
 Lung Diseases Antibodies  >4 publications with GRP94 and Lung Diseases
 Liver Neoplasms Antibodies  >3 publications with GRP94 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with GRP94 and Carcinoma, Hepatocellular
 Testicular Diseases Antibodies  >2 publications with GRP94 and Testicular Diseases
 Hyperplasia Antibodies  >2 publications with GRP94 and Hyperplasia
 Nervous System Diseases Antibodies  >2 publications with GRP94 and Nervous System Diseases
 Breast Neoplasms Antibodies  >2 publications with GRP94 and Breast Neoplasms

Organs/Tissues associated with anti-GRP94 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with GRP94 and Brain
 Liver Antibodies  >4 publications with GRP94 and Liver
 Testis Antibodies  >3 publications with GRP94 and Testis
 Female Genital Antibodies  >2 publications with GRP94 and Female Genital
 Thyroid Antibodies  >2 publications with GRP94 and Thyroid
 Pancreas Antibodies  >1 publications with GRP94 and Pancreas
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