GSTK1 Antibody – Rabbit Polyclonal

This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

GSTK1: Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB). Belongs to the GST superfamily. Kappa family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.5.1.18; Mitochondrial; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: intracellular; intracellular membrane-bound organelle; membrane; mitochondrial inner membrane; mitochondrial matrix; peroxisome

Molecular Function: glutathione peroxidase activity; glutathione transferase activity; protein binding; protein disulfide oxidoreductase activity; receptor binding

Biological Process: epithelial cell differentiation; glutathione metabolic process