GSTO1 Antibody – Mouse Monoclonal

The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GSTO1: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family.

Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Other Amino Acids Metabolism - glutathione; EC 2.5.1.18; EC 1.8.5.1; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.20.4.2; Transferase

Chromosomal Location of Human Ortholog: 10q25.1

Cellular Component: axon; basement membrane; cytoplasm; cytosol; myelin sheath; nuclear membrane

Molecular Function: glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; methylarsonate reductase activity; oxidoreductase activity; protein binding

Biological Process: glutathione metabolic process; L-ascorbic acid biosynthetic process; L-ascorbic acid metabolic process; methylation; positive regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion; xenobiotic catabolic process