GUCY1A3 Antibody – Rabbit Polyclonal

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GUCY1A3: Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Protein type: Nucleotide Metabolism - purine; EC 4.6.1.2; Lyase; Guanylyl cyclase; Receptor, misc.

Chromosomal Location of Human Ortholog: 4q31.1-q31.2

Cellular Component: guanylate cyclase complex, soluble; plasma membrane

Molecular Function: adenylate cyclase activity; GTP binding; guanylate cyclase activity; heme binding; protein binding; protein heterodimerization activity; receptor activity

Biological Process: blood circulation; cGMP biosynthetic process; nitric oxide mediated signal transduction; positive regulation of cGMP biosynthetic process; regulation of blood pressure; relaxation of vascular smooth muscle; response to defense-related host nitric oxide production; response to herbicide; response to organic cyclic substance

Disease: Moyamoya Disease 6 With Achalasia