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HAAO Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS769975

MBS769975 is an antibody targeting HAAO. Also known as HAAO Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
HAAO, Polyclonal Antibody
Full Product Name
HAAO Rabbit Polyclonal
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
17,275 Da
OMIM
604521
3D Structure
ModBase 3D Structure for P46952
Immunogen
3-hydroxyanthranilate 3, 4-dioxygenase
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-HAAO antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-HAAO antibody

Immunohistochemistry of paraffin-embedded human gliomas using MBS769975 (HAAO antibody) at dilution of 1:100
Rabbit Anti-HAAO Polyclonal Antibody – Cat# MBS769975

Western Blot (WB) of anti-HAAO antibody

human liver tissue were subjected to SDS PAGE followed by western blot with MBS769975 (HAAO antibody) at dilution of 1:300
Rabbit Anti-HAAO Polyclonal Antibody, Western Blot (WB) – Cat# MBS769975

Other Notes

Small volumes of anti-HAAO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HAAO. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
HAAO
NCBI Official Synonym Full Names
3-hydroxyanthranilate 3,4-dioxygenase
NCBI Official Symbol
HAAO
NCBI Official Synonym Symbols
HAO; 3-HAO
UniProt Protein Name
3-hydroxyanthranilate 3,4-dioxygenase
UniProt Synonym Protein Names
3-hydroxyanthranilate oxygenase
UniProt Gene Name
HAAO
UniProt Synonym Gene Names
3-HAO; HAD
UniProt Entry Name
3HAO_HUMAN
NCBI Protein Information
3-hydroxyanthranilate 3,4-dioxygenase

NCBI Summary for HAAO

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
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UniProt Comments for HAAO

HAAO: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Belongs to the 3-HAO family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.6; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: cytosol

Molecular Function: 3-hydroxyanthranilate 3,4-dioxygenase activity; electron carrier activity; ferrous iron binding; protein binding

Biological Process: anthranilate metabolic process; quinolinate biosynthetic process; quinolinate metabolic process; response to cadmium ion; response to zinc ion; tryptophan catabolic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-HAAO antibody

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