PKCZ: an AGC kinase of the PKC family. An atypical PKC: its activity is not regulated by Ca2+, PS, DAG or phorbol esters. Constitutively active.
Protein type: Protein kinase, AGC; Kinase, protein; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Iota subfamily
Cellular Component: tight junction; nuclear matrix; protein complex; intracellular membrane-bound organelle; apical cortex; leading edge; nuclear envelope; intercellular junction; cell cortex; cytosol; lipid raft; axon hillock; filamentous actin; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; plasma membrane; microtubule organizing center; cell junction; nucleus; endosome
Molecular Function: protein domain specific binding; protein kinase C activity; metal ion binding; nucleotide binding; protein kinase binding; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; phospholipase binding; potassium channel regulator activity; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding
Biological Process: protein heterooligomerization; membrane hyperpolarization; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of synaptic transmission; activation of NF-kappaB transcription factor; positive regulation of interleukin-4 production; positive regulation of glucose import; positive regulation of T-helper 2 cell differentiation; cell surface receptor linked signal transduction; negative regulation of hydrolase activity; positive regulation of cell proliferation; vesicle transport along microtubule; inflammatory response; positive regulation of cell-matrix adhesion; negative regulation of peptidyl-tyrosine phosphorylation; phospholipase D activation; cell migration; activation of protein kinase B; microtubule cytoskeleton organization and biogenesis; positive regulation of protein transport; membrane depolarization; peptidyl-serine phosphorylation; long-term memory; cellular response to insulin stimulus; establishment of cell polarity; actin cytoskeleton reorganization; insulin receptor signaling pathway; positive regulation of insulin receptor signaling pathway; negative regulation of protein complex assembly; phosphorylation; negative regulation of apoptosis
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