Transcobalamin II, Macrocytic Anemia (TCN2) ELISA Kit for Bovine

Name: Bovine TCN2 ELISA Kit; Transcobalamin II, Macrocytic Anemia; MyBioSource
Brand: MyBioSource
SKU: MBS078490
Price: 675 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS078490

MBS078490 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Transcobalamin II, Macrocytic Anemia (TCN2) ELISA Kit target analytes in biological samples. The concentration gradients of the… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Transcobalamin II, Macrocytic Anemia (TCN2), ELISA Kit

Full Product Name

Bovine Transcobalamin II, Macrocytic Anemia ELISA Kit

Product Gene Name

TCN2 elisa kit

Species Reactivity

Bovine

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

47,535 Da

OMIM

275350

3D Structure

ModBase 3D Structure for P20062

Other Notes

Small volumes of TCN2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TCN2. It may not necessarily be applicable to this product.

NCBI GI #

296080704

NCBI GeneID

6948

NCBI Accession #

NP_001171655.1

UniProt Primary Accession #

P20062

UniProt Secondary Accession #

Q96FD4; Q9BVI8; Q9UCI5; Q9UCI6; Q9UDM0

UniProt Related Accession #

P20062; AAB25526

GenBank Nucleotide #

NM_001184726.1

NCBI Official Full Name

transcobalamin-2 isoform 2

NCBI Official Synonym Full Names

transcobalamin II

NCBI Official Symbol

TCN2

NCBI Official Synonym Symbols

II; TC; TC2; TC-2; TCII; TC II; D22S676; D22S750

UniProt Protein Name

Transcobalamin-2

UniProt Synonym Protein Names

Transcobalamin II

Protein Family

Transcobalamin

UniProt Gene Name

TCN2

UniProt Synonym Gene Names

TC2; TC-2; TC II; TCII

UniProt Entry Name

TCO2_HUMAN

NCBI Protein Information

transcobalamin-2; macrocytic anemia; vitamin B12-binding protein 2; transcobalamin II; macrocytic anemia

NCBI Summary for TCN2

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

UniProt Comments for TCN2

TCN2: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency). This results in various forms of anemia. Belongs to the eukaryotic cobalamin transport proteins family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: lysosomal lumen; extracellular space; extracellular region; endosome

Molecular Function: metal ion binding; cobalamin binding

Biological Process: vitamin metabolic process; cobalamin metabolic process; cobalamin transport; cobalt ion transport; water-soluble vitamin metabolic process

Disease: Transcobalamin Ii Deficiency

Research Articles on TCN2

1. Report TCN2 mutations causing transcobalamin deficiency in a family.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TCN2 elisa kit

Reference Product	PubMed Publications
MTR elisa kit	>20 publications with TCN2 and MTR
DHFR elisa kit	>4 publications with TCN2 and DHFR
CD320 elisa kit	>4 publications with TCN2 and CD320
CBL elisa kit	>3 publications with TCN2 and CBL
MUT elisa kit	>2 publications with TCN2 and MUT
AK1 elisa kit	>1 publications with TCN2 and AK1

Pathways associated with TCN2 elisa kit

Products by Pathway	Pathway Diagram
Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway antibodies	Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway Diagram
Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies	Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
Defective BTD Causes Biotidinase Deficiency Pathway antibodies	Defective BTD Causes Biotidinase Deficiency Pathway Diagram
Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies	Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies	Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies	Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies	Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies	Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies	Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies	Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram

Diseases associated with TCN2 elisa kit

Disease Name	Pubmed Publications
TRANSCOBALAMIN II DEFICIENCY Antibodies	>12 publications with TCN2 and TRANSCOBALAMIN II DEFICIENCY
Nervous System Diseases Antibodies	>9 publications with TCN2 and Nervous System Diseases
Brain Diseases Antibodies	>5 publications with TCN2 and Brain Diseases
Anemia Antibodies	>5 publications with TCN2 and Anemia
Anemia, Megaloblastic Antibodies	>5 publications with TCN2 and Anemia, Megaloblastic
Cleft Lip Antibodies	>4 publications with TCN2 and Cleft Lip
Colorectal Neoplasms Antibodies	>3 publications with TCN2 and Colorectal Neoplasms
Kidney Diseases Antibodies	>2 publications with TCN2 and Kidney Diseases
Heart Diseases Antibodies	>2 publications with TCN2 and Heart Diseases
Autistic Disorder Antibodies	>2 publications with TCN2 and Autistic Disorder

Organs/Tissues associated with TCN2 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>28 publications with TCN2 and Blood
Heart Antibodies	>4 publications with TCN2 and Heart
Kidney Antibodies	>3 publications with TCN2 and Kidney
Brain Antibodies	>3 publications with TCN2 and Brain
Bone Marrow Antibodies	>2 publications with TCN2 and Bone Marrow
Muscle Antibodies	>1 publications with TCN2 and Muscle
Prostate Antibodies	>1 publications with TCN2 and Prostate
Bladder Antibodies	>1 publications with TCN2 and Bladder
Intestine Antibodies	>1 publications with TCN2 and Intestine
Vascular Antibodies	>1 publications with TCN2 and Vascular