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Bk Beta2 (KCNMB2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS800034

Background Info: No cross-reactivity against BKBeta1, BKBeta3 or BKBeta4.Scientific Background: BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release (3). A gain of function… More details

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Product Overview

Product Name
BK Beta2 (Kcnmb2), Monoclonal Antibody
Full Product Name
BK Beta2 Antibody: FITC
Product Gene Name
anti-Kcnmb2 antibody
Product Synonym Names
KCNMB2; Calcium-activated potassium channel subunit beta-2; BK channel subunit beta-2; BKbeta2; Calcium-activated potassium channel; subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2
Clonality
Monoclonal
Isotype
IgG1
Clone Number
S53-32
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Protein G Purified
Concentration
1mg/mL (lot specific)
Preparation and Storage
-20 degree C
Molecular Weight
27,120 Da
3D Structure
ModBase 3D Structure for Q9CZM9
Conjugate
FITC
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide

Product Categories/Family for anti-Kcnmb2 antibody

Ion Channels; Neuroscience
Applications Tested/Suitable for anti-Kcnmb2 antibody
Western (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes for anti-Kcnmb2 antibody
1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)

Immunohistochemistry (IHC) of anti-Kcnmb2 antibody

Immunohistochemistry analysis using Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody, Clone S53-32. Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Lower epidermal cells positive, but quite dull.
Mouse Anti-KCNMB2 Monoclonal Antibody – Cat# MBS800034

Western Blot (WB) of anti-Kcnmb2 antibody

Western Blot analysis of Human Cell line lysates showing detection of BK Beta2 Potassium Channel protein using Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody, Clone S53-32. Load: 15 ug. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.
Mouse Anti-KCNMB2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS800034

Immunocytochemistry/Immunofluorescence (ICC/IF) of anti-Kcnmb2 antibody

Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody, Clone S53-32. Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20 degree C. Primary Antibody: Mouse Anti-BK Beta2 Potassium Channel Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dottiness and dull.
Mouse Anti-KCNMB2 Monoclonal Antibody, Immunocytochemistry/Immunofluorescence (ICC/IF) – Cat# MBS800034

Product References and Citations for anti-Kcnmb2 antibody

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Wulf-Johansson H., et al. (2009) Brain Res. 1292: 1- 13. 4. Lee U.S., and Cui J. (2009) J Physiol. 587(7): 1481- 1489.

Other Notes

Small volumes of anti-Kcnmb2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Kcnmb2 purchase

MBS800034 is an antibody targeting Kcnmb2. Also known as BK Beta2 Antibody: FITC. Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Kcnmb2. It may not necessarily be applicable to this product.

NCBI GI #
21312300
NCBI GeneID
72413
NCBI Accession #
NP_082507.1
UniProt Primary Accession #
Q9CZM9
UniProt Related Accession #
Q9CZM9
GenBank Nucleotide #
NM_028231.2
NCBI Official Full Name
calcium-activated potassium channel subunit beta-2
NCBI Official Synonym Full Names
potassium large conductance calcium-activated channel, subfamily M, beta member 2
NCBI Official Symbol
Kcnmb2
NCBI Official Synonym Symbols
2700049B16Rik; 3110031N04Rik
UniProt Protein Name
Calcium-activated potassium channel subunit beta-2
UniProt Synonym Protein Names
BK channel subunit beta-2; BKbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2
Protein Family
Calcium-activated potassium channel
UniProt Gene Name
Kcnmb2
UniProt Synonym Gene Names
BKbeta2
UniProt Entry Name
KCMB2_MOUSE
NCBI Protein Information
calcium-activated potassium channel subunit beta-2; BKbeta2; slo-beta-2; k(VCA)beta-2; BK channel subunit beta-2; maxi K channel subunit beta-2; charybdotoxin receptor subunit beta-2; calcium-activated potassium channel, subfamily M subunit beta-2

UniProt Comments for Kcnmb2

KCNMB2: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: voltage-gated potassium channel complex; membrane; integral to plasma membrane; integral to membrane

Molecular Function: calcium-activated potassium channel activity; potassium channel regulator activity; potassium channel activity

Biological Process: synaptic transmission; regulation of action potential; transport; generation of action potential; ion transport; detection of calcium ion; potassium ion transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Kcnmb2 antibody

 Products by Pathway  Pathway Diagram
 Ca2+ Activated K+ Channels Pathway antibodies  Ca2+ Activated K+ Channels Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Nitric Oxide Stimulates Guanylate Cyclase Pathway antibodies  Nitric Oxide Stimulates Guanylate Cyclase Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 CGMP Effects Pathway antibodies  CGMP Effects Pathway Diagram

Diseases associated with anti-Kcnmb2 antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >1 publications with Kcnmb2 and Fibrosis

Organs/Tissues associated with anti-Kcnmb2 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with Kcnmb2 and Eye
 Brain Antibodies  >1 publications with Kcnmb2 and Brain
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