Rat Anti-TCP1 Monoclonal Antibody – Cat# MBS800063

Western Blot analysis of Human A431 and HEK293 cell lysates showing detection of TCP1 alpha protein using Rat Anti-TCP1 alpha Monoclonal Antibody, Clone 91a. Primary Antibody: Rat Anti-TCP1 alpha Monoclonal Antibody at 1:1000.

Alpha (TCP1) Antibody – Rat Monoclonal

Name: TCP1 Antibody; Monoclonal; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS800063
Price: 550 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS800063

Background Info: Detects a 60kDa protein corresponding to the molecular weight of TCP1 alpha; also detects a molecular mass band of ~92kDa. Cross reactivity with human Hsp60 has been observed with this antibody in immunoblot analysis.Scientific Background:… More details

$550 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TCP1-alpha, Monoclonal Antibody

Full Product Name

TCP1 alpha Antibody: ATTO 390

Product Gene Name

anti-Tcp1 antibody

Product Synonym Names

p63; Tcp-1; TCP1 alpha; Ccta; TRic; Tp63; 21454; c-cpn; CCT; Tcp1; ccpn; AI528772; Cct1; Tcp 1; c cpn

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

91a

Host

Rat

Species Reactivity

Mouse, Rat, Rabbit, Guinea pig, Hamster, Cow, Dog, Human, Pig, Saccharomyces cerevisiae, Caenorhabditis elegans, Fruit fly (Drosophila melanogaster), Monkey

Form/Format

Protein G Purified

Concentration

1mg/ml (lot specific)

Preparation and Storage

-20 degree C

Matching Pairs

Unconjugated Antibody: N/A (MBS800063)
ATTO 390 Conjugated Antibody: TCP1-alpha Clone #91a (MBS800063)

Matching Pairs

Unconjugated Antibody: TCP1-alpha Clone #91a (MBS804729)
ATTO 390 Conjugated Antibody: TCP1-alpha Clone #91a (MBS800063)

Molecular Weight

55,459 Da

3D Structure

ModBase 3D Structure for P11983

Conjugate

ATTO 390

Storage Buffer

PBS pH7.4, 50% glycerol, 0.1% sodium azide

Product Categories/Family for anti-Tcp1 antibody

Heat Shock

Applications Tested/Suitable for anti-Tcp1 antibody

Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)

Application Notes for anti-Tcp1 antibody

1:1000 (WB)

Other Notes

Small volumes of anti-Tcp1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tcp1 purchase

MBS800063 is an antibody targeting Tcp1. Also known as TCP1 alpha Antibody: ATTO 390. Reactive in Mouse, Rat, Rabbit, Guinea pig, Hamster, Cow, Dog, Human, Pig, Saccharomyces cerevisiae, Caenorhabditis elegans, Fruit fly (Drosophila melanogaster), Monkey. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for Tcp1. It may not necessarily be applicable to this product.

NCBI GI #

110625624

NCBI GeneID

21454

NCBI Accession #

NP_038714.2

UniProt Primary Accession #

P11983

UniProt Secondary Accession #

P11984; Q3TJ96; Q3TKU1; Q3U5T8; Q3U7I8; Q3UAA8; Q3UB80; Q3UE48

UniProt Related Accession #

P11983

GenBank Nucleotide #

NM_013686.4

NCBI Official Full Name

T-complex protein 1 subunit alpha isoform 1

NCBI Official Synonym Full Names

t-complex protein 1

NCBI Official Symbol

Tcp1

NCBI Official Synonym Symbols

CCT; p63; Cct1; Ccta; TRic; Tp63; Tcp-1; c-cpn; AI528772

UniProt Protein Name

T-complex protein 1 subunit alpha

UniProt Synonym Protein Names

CCT-alpha; Tailless complex polypeptide 1A; TCP-1-A; Tailless complex polypeptide 1B; TCP-1-B

Protein Family

T-complex protein

UniProt Gene Name

Tcp1

UniProt Synonym Gene Names

Cct1; Ccta; TCP-1-alpha; TCP-1-A; TCP-1-B

UniProt Entry Name

TCPA_MOUSE

NCBI Protein Information

T-complex protein 1 subunit alpha; TCP-1-A; TCP-1-B; CCT-alpha; TCP-1-alpha; t-complex polypeptide 1; tailless complex polypeptide 1A; tailless complex polypeptide 1B; T-complex protein 1 subunit alpha A; T-complex protein 1 subunit alpha B

UniProt Comments for Tcp1

CCT-alpha: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Belongs to the TCP-1 chaperonin family.

Protein type: Motility/polarity/chemotaxis; Chaperone

Cellular Component: heterochromatin; Golgi apparatus; chaperonin-containing T-complex; centrosome; microtubule; pericentriolar material; cytoskeleton; cytoplasm; acrosome; microtubule organizing center; nuclear heterochromatin; myelin sheath

Molecular Function: protein binding; ubiquitin protein ligase binding; unfolded protein binding; nucleotide binding; ATP binding

Biological Process: protein folding; binding of sperm to zona pellucida

Research Articles on Tcp1

1. Our data provide new evidence indicating the essential role of the chaperonin CCT in the biogenesis of vertebrate photoreceptor sensory cilia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Tcp1 antibody

Products by Pathway	Pathway Diagram
Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies	Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram
Chaperonin-mediated Protein Folding Pathway antibodies	Chaperonin-mediated Protein Folding Pathway Diagram
Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway antibodies	Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway Diagram
Folding Of Actin By CCT/TriC Pathway antibodies	Folding Of Actin By CCT/TriC Pathway Diagram
Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway antibodies	Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Prefoldin Mediated Transfer Of Substrate To CCT/TriC Pathway antibodies	Prefoldin Mediated Transfer Of Substrate To CCT/TriC Pathway Diagram
Protein Folding Pathway antibodies	Protein Folding Pathway Diagram

Diseases associated with anti-Tcp1 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>9 publications with Tcp1 and Carcinoma
Cardiovascular Diseases Antibodies	>5 publications with Tcp1 and Cardiovascular Diseases
Inflammation Antibodies	>5 publications with Tcp1 and Inflammation
Immune System Diseases Antibodies	>5 publications with Tcp1 and Immune System Diseases
Heart Diseases Antibodies	>3 publications with Tcp1 and Heart Diseases
Lung Neoplasms Antibodies	>3 publications with Tcp1 and Lung Neoplasms
Lung Diseases Antibodies	>3 publications with Tcp1 and Lung Diseases
Carcinoma, Hepatocellular Antibodies	>2 publications with Tcp1 and Carcinoma, Hepatocellular
Necrosis Antibodies	>2 publications with Tcp1 and Necrosis
Prostatic Neoplasms Antibodies	>2 publications with Tcp1 and Prostatic Neoplasms

Organs/Tissues associated with anti-Tcp1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>15 publications with Tcp1 and Blood
Testis Antibodies	>15 publications with Tcp1 and Testis
Brain Antibodies	>11 publications with Tcp1 and Brain
Heart Antibodies	>6 publications with Tcp1 and Heart
Liver Antibodies	>5 publications with Tcp1 and Liver
Kidney Antibodies	>4 publications with Tcp1 and Kidney
Lung Antibodies	>4 publications with Tcp1 and Lung
Muscle Antibodies	>4 publications with Tcp1 and Muscle
Ovary Antibodies	>3 publications with Tcp1 and Ovary
Spinal Cord Antibodies	>3 publications with Tcp1 and Spinal Cord