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SLC17A7 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS800216

Background Info: Detects ~52kDa. No cross-reactivity against VGLUT2.Scientific Background: VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that… More details

$510 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
VGLUT1 (Slc17a7), Monoclonal Antibody
Full Product Name
VGLUT1 Antibody
Product Gene Name
anti-Slc17a7 antibody
Product Synonym Names
BNPI; SLC17A1; SLC17A1/VGLUT1; Solute Carrier family 17 member 7; Vesicular glutamate transporter 1; VGLUT 1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter
Clonality
Monoclonal
Isotype
IgG1
Clone Number
S28-9
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Protein G Purified
Concentration
1mg/mL (lot specific)
Preparation and Storage
-20 degree C
Matching Pairs
Antibody: N/A (MBS800216)
Antibody: VGLUT1 Clone #S28-9 (MBS800216)
Matching Pairs
Unconjugated Antibody: VGLUT1 Clone #S28-9 (MBS800216)
Biotin Conjugated Antibody: VGLUT1 Clone #S28-9 (MBS801649)
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Molecular Weight
64,333 Da
3D Structure
ModBase 3D Structure for Q62634
Certificate of Analysis
1ug/mL was sufficient for detection of VGLut1 in 20ug of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide.

Product Categories/Family for anti-Slc17a7 antibody

Transporters
Applications Tested/Suitable for anti-Slc17a7 antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-Slc17a7 antibody
1:1000 (WB)

Immunohistochemistry (IHC) of anti-Slc17a7 antibody

Immunohistochemistry analysis using Mouse Anti-VGLUT1 Monoclonal Antibody, Clone S28-9. Tissue: spinal cord. Species: Mouse. Fixation: 4% PFA. Primary Antibody: Mouse Anti-VGLUT1 Monoclonal Antibody at 1:500 for 16 hours at RT. Secondary Antibody: Alexa Fluor 555 Donkey Anti-Mouse (red) at 1:2000 for 2 hours at RT. Counterstain: NeuN neuronal stain (green). Magnification: 20X. Courtesy of: Leilei Wang, Ph.D. UT Southwestern Medical Center at Dallas.
Mouse Anti-SLC17A7 Monoclonal Antibody – Cat# MBS800216

Western Blot (WB) of anti-Slc17a7 antibody

Western Blot analysis of Rat brain membrane lysate showing detection of VGLUT1 protein using Mouse Anti-VGLUT1 Monoclonal Antibody, Clone S28-9. Primary Antibody: Mouse Anti-VGLUT1 Monoclonal Antibody at 1:1000.
Mouse Anti-SLC17A7 Monoclonal Antibody, Western Blot (WB) – Cat# MBS800216

Product References and Citations for anti-Slc17a7 antibody

1. Wojcik S.M., et al. (2004) PNAS. 101(18): 7158-7163. 2.   Shigeri Y., Seal R.P., Shimamoto K. (2004) Brain Res Rev. 45(3): 250-265.

Other Notes

Small volumes of anti-Slc17a7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Slc17a7 purchase

MBS800216 is an antibody targeting Slc17a7. Also known as VGLUT1 Antibody. Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Slc17a7. It may not necessarily be applicable to this product.

NCBI GI #
16758726
NCBI GeneID
116638
NCBI Accession #
NP_446311.1
UniProt Primary Accession #
Q62634
UniProt Secondary Accession #
A9LRT0
UniProt Related Accession #
Q62634
GenBank Nucleotide #
NM_053859.2
NCBI Official Full Name
vesicular glutamate transporter 1
NCBI Official Synonym Full Names
solute carrier family 17 (vesicular glutamate transporter), member 7
NCBI Official Symbol
Slc17a7
NCBI Official Synonym Symbols
BNPI; Vglut1
UniProt Protein Name
Vesicular glutamate transporter 1
UniProt Synonym Protein Names
Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7
Protein Family
Vesicular glutamate transporter
UniProt Gene Name
Slc17a7
UniProt Synonym Gene Names
Bnpi; Vglut1; VGluT1
UniProt Entry Name
VGLU1_RAT
NCBI Protein Information
vesicular glutamate transporter 1; solute carrier family 17 member 7; brain-specific Na-dependent inorganic phosphate cotransporter; brain-specific Na(+)-dependent inorganic phosphate cotransporter; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7

NCBI Summary for Slc17a7

a Na(+)-dependent inorganic phosphate cotransporter; may be involved in neuronal Na+ transport [RGD, Feb 2006]

UniProt Comments for Slc17a7

SLC17A7: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

Protein type: Vesicle; Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: synaptic vesicle; synaptic vesicle membrane; integral to membrane; presynaptic active zone; excitatory synapse; intracellular organelle; synapse; cell junction

Molecular Function: sodium:inorganic phosphate symporter activity; extracellular-glutamate-gated chloride channel activity; sodium-dependent phosphate transmembrane transporter activity; inorganic phosphate transmembrane transporter activity

Biological Process: L-glutamate import; synaptic transmission, glutamatergic; synaptic transmission; long-term memory; phosphate transport; neurotransmitter transport; sequestering of neurotransmitter; regulation of excitatory postsynaptic membrane potential
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Research Articles on Slc17a7

1. The results indicated that glutamatergic spinal trigeminal nucleus neurons sending their axons to the cerebellar cortical regions mainly express VGLUT1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Slc17a7 antibody

 Products by Pathway  Pathway Diagram
 Glutamate Neurotransmitter Release Cycle Pathway antibodies  Glutamate Neurotransmitter Release Cycle Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Nicotine Addiction Pathway antibodies  Nicotine Addiction Pathway Diagram
 Nicotine Addiction Pathway antibodies  Nicotine Addiction Pathway Diagram
 Organic Anion Transporters Pathway antibodies  Organic Anion Transporters Pathway Diagram
 Retrograde Endocannabinoid Signaling Pathway antibodies  Retrograde Endocannabinoid Signaling Pathway Diagram
 Retrograde Endocannabinoid Signaling Pathway antibodies  Retrograde Endocannabinoid Signaling Pathway Diagram

Diseases associated with anti-Slc17a7 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >43 publications with Slc17a7 and Nervous System Diseases
 Mental Disorders Antibodies  >37 publications with Slc17a7 and Mental Disorders
 Epilepsy Antibodies  >11 publications with Slc17a7 and Epilepsy
 Learning Disorders Antibodies  >11 publications with Slc17a7 and Learning Disorders
 Memory Disorders Antibodies  >10 publications with Slc17a7 and Memory Disorders
 Pain Antibodies  >9 publications with Slc17a7 and Pain
 Neurobehavioral Manifestations Antibodies  >8 publications with Slc17a7 and Neurobehavioral Manifestations
 Seizures Antibodies  >6 publications with Slc17a7 and Seizures
 Cognition Disorders Antibodies  >5 publications with Slc17a7 and Cognition Disorders
 Nerve Degeneration Antibodies  >5 publications with Slc17a7 and Nerve Degeneration

Organs/Tissues associated with anti-Slc17a7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >251 publications with Slc17a7 and Brain
 Nerve Antibodies  >92 publications with Slc17a7 and Nerve
 Eye Antibodies  >21 publications with Slc17a7 and Eye
 Dorsal Root Ganglion Antibodies  >7 publications with Slc17a7 and Dorsal Root Ganglion
 Pineal Gland Antibodies  >3 publications with Slc17a7 and Pineal Gland
 Inner Ear Antibodies  >2 publications with Slc17a7 and Inner Ear
 Heart Antibodies  >2 publications with Slc17a7 and Heart
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