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Ryanodine Receptor 2, Cardiac (RYR2) ELISA Kit for Rat

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS080022

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of RYR2 (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates,… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ryanodine Receptor 2, Cardiac (RYR2), ELISA Kit
Full Product Name
Rat Ryanodine Receptor 2, Cardiac ELISA Kit
Product Gene Name
RYR2 elisa kit
Species Reactivity
Rat
Assay Type
Sandwich
Samples
Undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Detection Range
31.2 pg/ml -1000 pg/ml.
Sensitivity
5.0 pg/ml.
Specificity
No significant cross-reactivity or interference between this analyte and analogues is observed.
Preparation and Storage
Store all reagents at 2-8 degree C
Inter-assay Precision
Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
Intra-assay Precision
Intra-assay CV (%) is less than 15%.
Molecular Weight
564,567 Da
OMIM
180902
3D Structure
ModBase 3D Structure for Q92736

Other Notes

Small volumes of RYR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RYR2 purchase

MBS080022 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Ryanodine Receptor 2, Cardiac (RYR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing RYR2. The ELISA analytical biochemical technique of the MBS080022 kit is based on RYR2 antibody-RYR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RYR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, RYR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for RYR2. It may not necessarily be applicable to this product.

NCBI GI #
112799847
NCBI GeneID
6262
NCBI Accession #
NP_001026.2
UniProt Primary Accession #
Q92736
UniProt Secondary Accession #
Q15411; Q546N8; Q5T3P2
UniProt Related Accession #
Q92736
GenBank Nucleotide #
NM_001035.2
NCBI Official Full Name
ryanodine receptor 2
NCBI Official Synonym Full Names
ryanodine receptor 2 (cardiac)
NCBI Official Symbol
RYR2
NCBI Official Synonym Symbols
RyR; ARVC2; ARVD2; RYR-2; VTSIP
UniProt Protein Name
Ryanodine receptor 2
UniProt Synonym Protein Names
Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor
Protein Family
Ryanodine receptor
UniProt Gene Name
RYR2
UniProt Synonym Gene Names
RYR-2; RyR2; hRYR-2
UniProt Entry Name
RYR2_HUMAN
NCBI Protein Information
ryanodine receptor 2; type 2 ryanodine receptor; islet-type ryanodine receptor; kidney-type ryanodine receptor; cardiac-type ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel

NCBI Summary for RYR2

This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]
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UniProt Comments for RYR2

RYR2: ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described.

Protein type: Membrane protein, multi-pass; Transporter, ion channel; Transporter; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; protein complex; sarcoplasmic reticulum; membrane; plasma membrane; Z disc

Molecular Function: calcium-induced calcium release activity; calmodulin binding; identical protein binding; protein binding; enzyme binding; protein self-association; calcium-release channel activity; calcium channel activity; calcium ion binding; intracellular ligand-gated calcium channel activity; ryanodine-sensitive calcium-release channel activity

Biological Process: positive regulation of sequestering of calcium ion; cytosolic calcium ion homeostasis; regulation of heart rate; calcium-mediated signaling; positive regulation of heart rate; response to redox state; Wnt receptor signaling pathway through beta-catenin; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to caffeine; BMP signaling pathway; cellular calcium ion homeostasis; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; detection of calcium ion; transmembrane transport; cardiac muscle contraction

Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Arrhythmogenic Right Ventricular Dysplasia, Familial, 2
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Research Articles on RYR2

1. CPVT is an inherited cardiac disorder in which patients have structurally normal hearts but increased risk of stress-induced ventricular arrhythmias because of mutations in the cardiac "ryanodine receptor 2" (RyR2; CPVT1)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RYR2 elisa kit

 Reference Product  PubMed Publications
 TRDN elisa kit  >45 publications with RYR2 and TRDN
 CACNA1S elisa kit  >24 publications with RYR2 and CACNA1S
 NOS1 elisa kit  >13 publications with RYR2 and NOS1
 CACNA1C elisa kit  >6 publications with RYR2 and CACNA1C
 AKAP6 elisa kit  >6 publications with RYR2 and AKAP6
 FKBP1B elisa kit  >5 publications with RYR2 and FKBP1B
 PKD2L1 elisa kit  >1 publications with RYR2 and PKD2L1

Pathways associated with RYR2 elisa kit

 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram

Diseases associated with RYR2 elisa kit

 Disease Name  Pubmed Publications
 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY Antibodies  >18365 publications with RYR2 and VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY
 Heart Diseases Antibodies  >946 publications with RYR2 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >552 publications with RYR2 and Arrhythmias, Cardiac
 Nervous System Diseases Antibodies  >445 publications with RYR2 and Nervous System Diseases
 Heart Failure Antibodies  >436 publications with RYR2 and Heart Failure
 Tachycardia Antibodies  >345 publications with RYR2 and Tachycardia
 Tachycardia, Ventricular Antibodies  >328 publications with RYR2 and Tachycardia, Ventricular
 Disease Models, Animal Antibodies  >230 publications with RYR2 and Disease Models, Animal
 Cardiomyopathies Antibodies  >150 publications with RYR2 and Cardiomyopathies
 Cardiomegaly Antibodies  >109 publications with RYR2 and Cardiomegaly
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