Glun1-NR1 (GRIN1) Antibody – Mouse Monoclonal

NMDAR1: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described.

Protein type: Channel, calcium; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated

Cellular Component: cell surface; cell; endoplasmic reticulum; integral to plasma membrane; dendrite; postsynaptic density; dendritic spine; excitatory synapse; terminal button; N-methyl-D-aspartate selective glutamate receptor complex; postsynaptic membrane; synaptic vesicle; cell soma; membrane; cytoplasm; synapse; cell junction

Molecular Function: voltage-gated cation channel activity; protein dimerization activity; neurotransmitter binding; glutamate receptor binding; calcium channel activity; calcium ion binding; calmodulin binding; protein binding; enzyme binding; extracellular-glutamate-gated ion channel activity; glutamate binding; ionotropic glutamate receptor activity; protein heterodimerization activity; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; cation channel activity; receptor binding

Biological Process: regulation of long-term neuronal synaptic plasticity; startle response; male mating behavior; prepulse inhibition; positive regulation of apoptosis; adult locomotory behavior; regulation of dendrite morphogenesis; rhythmic process; regulation of synaptic plasticity; response to morphine; regulation of axonogenesis; sensory perception of pain; response to organic cyclic substance; calcium ion homeostasis; regulation of respiratory gaseous exchange; learning and/or memory; calcium ion transport; conditioned taste aversion; regulation of neuron apoptosis; visual learning; negative regulation of neuron apoptosis; associative learning; cation transport; protein tetramerization; synaptic transmission, glutamatergic; neuromuscular process; response to amphetamine; learning; respiratory gaseous exchange; social behavior; pons maturation; memory; cellular calcium ion homeostasis; regulation of membrane potential; response to ethanol; suckling behavior; olfactory learning; regulation of synaptogenesis; long-term memory; propylene metabolic process; ionotropic glutamate receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; response to calcium ion; regulation of excitatory postsynaptic membrane potential; response to amine stimulus; regulation of neuronal synaptic plasticity