Mouse Anti-SLC1A1 Monoclonal Antibody – Cat# MBS800775

Western Blot analysis of Rat brain membrane lysate showing detection of EAAT3 protein using Mouse Anti-EAAT3 Monoclonal Antibody, Clone S180-41. Primary Antibody: Mouse Anti-EAAT3 Monoclonal Antibody at 1:1000.

SLC1A1 Antibody – Mouse Monoclonal

Name: SLC1A1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS800775
Price: 535 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS800775

Background Info: Detects ~60kDaScientific Background: SLC1A1/EAAT3/EAAC1, a member of this transporter family, is expressed throughout the body, particularly in brain, intestine, liver, heart and kidney. Functional defects of the SLC1A1 gene are found in… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

EAAC1 (SLC1A1), Monoclonal Antibody

Full Product Name

EAAC1 Antibody: Alkaline Phosphatase

Product Gene Name

anti-SLC1A1 antibody

Product Synonym Names

Excitatory amino-acid carrier 1; excitatory amino acid transporter 3; EAAT3; Neuronal and epithelial glutamate transporter; sodium dependent glutamate/aspartate transporter 3; solute carrier family 1 member 1; and Slc1a1

Clonality

Monoclonal

Isotype

IgG1

Clone Number

S180-41

Host

Mouse

Species Reactivity

Human

Form/Format

Protein G Purified

Concentration

1mg/mL (lot specific)

Preparation and Storage

-20 degree C

Molecular Weight

57,100 Da

OMIM

gene 615232

3D Structure

ModBase 3D Structure for P43005

Conjugate

Alkaline Phosphatase

Storage Buffer

PBS pH7.2, 50% glycerol, 0.09% sodium azide

Product Categories/Family for anti-SLC1A1 antibody

Transporters

Applications Tested/Suitable for anti-SLC1A1 antibody

Immunoprecipitation (IP)

Application Notes for anti-SLC1A1 antibody

1:1000 (WB)

Product References and Citations for anti-SLC1A1 antibody

1. Smith C. P., et al., (1994) Genomics 20:335-336. 2. Kanai Y., and Hediger M. A. (1992) Nature 360:467-471.

Other Notes

Small volumes of anti-SLC1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC1A1 purchase

MBS800775 is an antibody targeting SLC1A1. Also known as EAAC1 Antibody: Alkaline Phosphatase. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC1A1. It may not necessarily be applicable to this product.

NCBI GI #

66773030

NCBI GeneID

6505

NCBI Accession #

NP_004161

UniProt Primary Accession #

P43005

UniProt Secondary Accession #

O75587; Q5VZ24; Q8N199; Q9UEW2

UniProt Related Accession #

P43005

GenBank Nucleotide #

NM_004170.5

NCBI Official Full Name

excitatory amino acid transporter 3

NCBI Official Synonym Full Names

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

NCBI Official Symbol

SLC1A1

NCBI Official Synonym Symbols

DCBXA; EAAC1; EAAT3; SCZD18

UniProt Protein Name

Excitatory amino acid transporter 3

UniProt Synonym Protein Names

Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1

Protein Family

Excitatory amino acid transporter

UniProt Gene Name

SLC1A1

UniProt Synonym Gene Names

EAAC1; EAAT3

UniProt Entry Name

EAA3_HUMAN

NCBI Protein Information

excitatory amino acid transporter 3; excitatory amino acid carrier 1; solute carrier family 1 member 1; neuronal and epithelial glutamate transporter; sodium-dependent glutamate/aspartate transporter 3

NCBI Summary for SLC1A1

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

UniProt Comments for SLC1A1

SLC1A1: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: membrane; integral to plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: glutamate binding; cysteine transmembrane transporter activity; sodium:dicarboxylate symporter activity; glutamate:sodium symporter activity; L-glutamate transmembrane transporter activity

Biological Process: synaptic transmission; L-glutamate import; cysteine transport; ion transport; transmembrane transport; protein homooligomerization

Disease: Schizophrenia 18

Research Articles on SLC1A1

1. internalization of EAAT3 triggered by amphetamine increases glutamatergic signaling and thus contributes to the effects of amphetamine on neurotransmission.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC1A1 antibody

Reference Product	PubMed Publications
ARL6IP5 antibody	>9 publications with SLC1A1 and ARL6IP5
PRKCA antibody	>3 publications with SLC1A1 and PRKCA

Pathways associated with anti-SLC1A1 antibody

Products by Pathway	Pathway Diagram
Glutamate Neurotransmitter Release Cycle Pathway antibodies	Glutamate Neurotransmitter Release Cycle Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Neurotransmitter Release Cycle Pathway antibodies	Neurotransmitter Release Cycle Pathway Diagram
Protein Digestion And Absorption Pathway antibodies	Protein Digestion And Absorption Pathway Diagram
Protein Digestion And Absorption Pathway antibodies	Protein Digestion And Absorption Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram
Transmission Across Chemical Synapses Pathway antibodies	Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with anti-SLC1A1 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>76 publications with SLC1A1 and Nervous System Diseases
Brain Diseases Antibodies	>60 publications with SLC1A1 and Brain Diseases
Disease Models, Animal Antibodies	>35 publications with SLC1A1 and Disease Models, Animal
Epilepsy Antibodies	>22 publications with SLC1A1 and Epilepsy
Seizures Antibodies	>15 publications with SLC1A1 and Seizures
Pain Antibodies	>9 publications with SLC1A1 and Pain
Movement Disorders Antibodies	>8 publications with SLC1A1 and Movement Disorders
Nerve Degeneration Antibodies	>6 publications with SLC1A1 and Nerve Degeneration
Epilepsy, Temporal Lobe Antibodies	>6 publications with SLC1A1 and Epilepsy, Temporal Lobe
Atrophy Antibodies	>6 publications with SLC1A1 and Atrophy

Organs/Tissues associated with anti-SLC1A1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>201 publications with SLC1A1 and Brain
Kidney Antibodies	>25 publications with SLC1A1 and Kidney
Eye Antibodies	>21 publications with SLC1A1 and Eye
Intestine Antibodies	>16 publications with SLC1A1 and Intestine
Muscle Antibodies	>8 publications with SLC1A1 and Muscle
Liver Antibodies	>6 publications with SLC1A1 and Liver
Bone Antibodies	>6 publications with SLC1A1 and Bone
Embryonic Tissue Antibodies	>5 publications with SLC1A1 and Embryonic Tissue
Vascular Antibodies	>4 publications with SLC1A1 and Vascular
Uterus Antibodies	>4 publications with SLC1A1 and Uterus