Glua1/Glur1 Glutamate Receptor (GRIA1) Antibody – Mouse Monoclonal

GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated

Cellular Component: endoplasmic reticulum membrane; neuron projection; cell surface; protein complex; endoplasmic reticulum; early endosome; dendrite; postsynaptic density; integral to membrane; dendritic spine; excitatory synapse; cytosol; asymmetric synapse; postsynaptic membrane; recycling endosome; synaptic vesicle; membrane; cell soma; plasma membrane; ionotropic glutamate receptor complex; synapse; dendritic shaft; cell junction; neuromuscular junction

Molecular Function: identical protein binding; protein domain specific binding; protein homodimerization activity; myosin V binding; G-protein alpha-subunit binding; G-protein beta-subunit binding; protein kinase binding; PDZ domain binding; small GTPase binding; protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; beta-2 adrenergic receptor binding; protein kinase A binding; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; adenylate cyclase binding

Biological Process: response to drug; regulation of synaptic transmission; response to peptide hormone stimulus; synaptic transmission, glutamatergic; response to lithium ion; response to toxin; response to arsenic; generation of action potential; regulation of synaptic plasticity; response to cocaine; response to organic cyclic substance; response to estradiol stimulus; positive regulation of synaptic transmission; synaptic transmission; long-term memory; ionotropic glutamate receptor signaling pathway; spinal cord development; receptor internalization; regulation of receptor recycling; response to electrical stimulus; positive regulation of membrane potential