DICER1 Antibody – Mouse Monoclonal

DICER1: a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described.

Protein type: Ribonuclease; RNA-binding; Helicase; Cell development/differentiation; RNA processing; EC 3.1.26.3

Cellular Component: growth cone; axon; dendrite; cytoplasm; ER-Golgi intermediate compartment; nucleus

Molecular Function: nuclease activity; miRNA binding; hydrolase activity; RNA binding; metal ion binding; nucleotide binding; deoxyribonuclease I activity; endoribonuclease activity, producing 5'-phosphomonoesters; helicase activity; endoribonuclease activity; protein binding; ribonuclease III activity; nucleic acid binding; endonuclease activity; double-stranded RNA binding; ATP binding

Biological Process: regulation of myelination; regulation of neuron differentiation; regulation of cell cycle; anatomical structure development; rRNA catabolic process; miRNA-mediated gene silencing, miRNA loading onto RISC; post-embryonic development; RNA processing; regulation of Notch signaling pathway; hair follicle development; pre-microRNA processing; RNA-mediated gene silencing; defense response to virus; meiotic spindle organization and biogenesis; regulation of odontogenesis of dentine-containing teeth; embryonic limb morphogenesis; spleen development; mRNA stabilization; RNA interference, targeting of mRNA for destruction; RNA interference, conversion of ds siRNA to ss siRNA; miRNA-mediated gene silencing, production of miRNAs; branching morphogenesis of a tube; regulation of gene expression; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; RNA interference, production of siRNA; myoblast cell differentiation involved in skeletal muscle regeneration; zygote asymmetric cell division; regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; olfactory bulb interneuron differentiation; embryonic hindlimb morphogenesis; cardiac muscle cell development; regulation of neurogenesis; epidermis morphogenesis; regulation of cell differentiation; DNA fragmentation during apoptosis; angiogenesis; regulation of viral genome replication; positive regulation of myelination; regulation of protein amino acid phosphorylation; positive regulation of Schwann cell differentiation; hair follicle morphogenesis; inner ear receptor cell development; multicellular organism growth; stem cell maintenance; spindle assembly; spinal cord motor neuron differentiation; cell proliferation; myelin formation in the peripheral nervous system; gut development; cartilage development; regulation of RNA metabolic process; nerve development; reproductive structure development; neurite morphogenesis; lung development