Copper-Transporting Atpase1 (ATP7A) Antibody – Mouse Monoclonal

This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013]

ATP7A: a multi-pass membrane protein and cation transporting ATPase. A copper-transporter that may supply copper to copper-requiring proteins within the secretory pathway when localized in the trans-Golgi network. Cycles between the trans-Golgi network (TGN) and the plasma membrane. Predominantly found in the TGN and relocalizes to the plasma membrane in response to elevated extracellular copper levels where it functions in the efflux of copper from cells. Defects in ATP7A are the cause of Menkes syndrome (MD) and occipital horn syndrome (OHS). Six alternatively spliced isoforms have been described. The longest isoform has 6 transmembrane regions. Isoform 3, lacking all 6 transmembrane regions and 5 heavy-metal-associated (HMA) domains, is probably cytosolic. Isoform 6 lacks all transmembrane regions and 5 heavy-metal-associated (HMA) domains, but has a putative nuclear localization signal attached at the N-terminus.

Protein type: Membrane protein, integral; Hydrolase; Vesicle; Membrane protein, multi-pass; Transporter, ion channel; Cell development/differentiation; Chaperone; Transporter; EC 3.6.3.54; Apoptosis

Chromosomal Location of Human Ortholog: Xq21.1

Cellular Component: Golgi apparatus; neuron projection; brush border membrane; endoplasmic reticulum; basolateral plasma membrane; integral to membrane; trans-Golgi network; cytosol; secretory granule; trans-Golgi network transport vesicle; membrane; cell soma; perinuclear region of cytoplasm; late endosome; plasma membrane

Molecular Function: copper ion transmembrane transporter activity; protein binding; copper ion binding; copper-exporting ATPase activity; superoxide dismutase copper chaperone activity; ATP binding; copper-dependent protein binding

Biological Process: lactation; skin development; positive regulation of catalytic activity; extracellular matrix organization and biogenesis; collagen fibril organization; removal of superoxide radicals; catecholamine metabolic process; pyramidal neuron development; locomotory behavior; norepinephrine metabolic process; dopamine metabolic process; norepinephrine biosynthetic process; peptidyl-lysine modification; epinephrine metabolic process; tryptophan metabolic process; plasma membrane copper ion transport; negative regulation of neuron apoptosis; transmembrane transport; serotonin metabolic process; central nervous system neuron development; positive regulation of oxidoreductase activity; blood vessel development; mitochondrion organization and biogenesis; release of cytochrome c from mitochondria; negative regulation of metalloenzyme activity; hair follicle morphogenesis; cellular copper ion homeostasis; response to iron(III) ion; in utero embryonic development; T-helper cell differentiation; dendrite morphogenesis; tyrosine metabolic process; detoxification of copper ion; positive regulation of metalloenzyme activity; copper ion transport; ATP metabolic process; elastin biosynthetic process; elastic fiber assembly; response to reactive oxygen species; pigmentation; response to zinc ion; regulation of gene expression; regulation of oxidative phosphorylation; cartilage development; cerebellar Purkinje cell differentiation; copper ion import; blood vessel remodeling; copper ion export; alveolus development; neurite morphogenesis

Disease: Occipital Horn Syndrome; Menkes Disease; Spinal Muscular Atrophy, Distal, X-linked 3