Mouse Anti-TRPC5 Monoclonal Antibody – Cat# MBS801745

Immunohistochemistry analysis using Mouse Anti-TrpC5 Monoclonal Antibody, Clone S67-15. Tissue: Brain Slice. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-TrpC5 Monoclonal Antibody at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 ul for 5 minutes at RT. Localization: Nuclear staining. Magnification: 10X.

TRPC5 Antibody – Mouse Monoclonal

Name: TRPC5 Antibody; Monoclonal; Mouse; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS801745
Price: 535 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS801745

Background Info: Detects ~110kDa.Scientific Background: Transient receptor potential cation channel, subfamily C, member 5, also known as TRPC5, is a subtype of the TRPC family of mammalian transient receptor potential ion channels. Homo-multimeric TRPC5 and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TrpC5, Monoclonal Antibody

Full Product Name

TrpC5 Antibody: Alkaline Phosphatase

Product Gene Name

anti-TRPC5 antibody

Product Synonym Names

Htrp5; Short transient receptor potential channel 5; TRP5

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

S67-15

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Form/Format

Protein G Purified

Concentration

1mg/mL (lot specific)

Preparation and Storage

-20 degree C

Molecular Weight

111,412 Da

OMIM

300334

3D Structure

ModBase 3D Structure for Q9UL62

Conjugate

Alkaline Phosphatase

Storage Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Product Categories/Family for anti-TRPC5 antibody

Ion Channels; Neuroscience

Applications Tested/Suitable for anti-TRPC5 antibody

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

Application Notes for anti-TRPC5 antibody

1ug/mL (WB), 0.1ug/mL (IHC/ICC), 1-10ug/mL (IF)

Product References and Citations for anti-TRPC5 antibody

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Xu S.Z., et al. (2008) Nature 451(7174): 69-72. 4. Bahnasi Y.M., et al. (2008) Br J. Pharamcol. 153(7): 1505-1512.

Other Notes

Small volumes of anti-TRPC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRPC5 purchase

MBS801745 is an antibody targeting TRPC5. Also known as TrpC5 Antibody: Alkaline Phosphatase. Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TRPC5. It may not necessarily be applicable to this product.

NCBI GI #

6912736

NCBI GeneID

7224

NCBI Accession #

NP_036603.1

UniProt Primary Accession #

Q9UL62

UniProt Secondary Accession #

O75233; Q5JXY8; Q9Y514; B2RP53

UniProt Related Accession #

Q9UL62

GenBank Nucleotide #

NM_012471.2

NCBI Official Full Name

short transient receptor potential channel 5

NCBI Official Synonym Full Names

transient receptor potential cation channel, subfamily C, member 5

NCBI Official Symbol

TRPC5

NCBI Official Synonym Symbols

TRP5; PPP1R159

UniProt Protein Name

Short transient receptor potential channel 5

UniProt Synonym Protein Names

Transient receptor protein 5; TRP-5; hTRP-5; hTRP5

Protein Family

Short transient receptor potential channel

UniProt Gene Name

TRPC5

UniProt Synonym Gene Names

TRP5; TrpC5; TRP-5; hTRP-5; hTRP5

UniProt Entry Name

TRPC5_HUMAN

NCBI Protein Information

short transient receptor potential channel 5; TRP-5; hTRP5; transient receptor protein 5; protein phosphatase 1, regulatory subunit 159

NCBI Summary for TRPC5

This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]

UniProt Comments for TRPC5

TRPC5: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.

Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; store-operated calcium channel activity; calcium channel activity

Biological Process: nervous system development; axon guidance; calcium ion transport; transmembrane transport

Research Articles on TRPC5

1. Riluzole can activate TRPC5 heterologously expressed in HEK293 cells as well as those endogenously expressed in the U-87 glioblastoma cell line.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRPC5 antibody

Reference Product	PubMed Publications
TRPC1 antibody	>126 publications with TRPC5 and TRPC1
TRPC4 antibody	>112 publications with TRPC5 and TRPC4
TRPC6 antibody	>102 publications with TRPC5 and TRPC6
TRPC3 antibody	>93 publications with TRPC5 and TRPC3
STIM1 antibody	>15 publications with TRPC5 and STIM1
FKBP4 antibody	>1 publications with TRPC5 and FKBP4

Pathways associated with anti-TRPC5 antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Netrin-1 Signaling Pathway antibodies	Netrin-1 Signaling Pathway Diagram
Role Of Second Messengers In Netrin-1 Signaling Pathway antibodies	Role Of Second Messengers In Netrin-1 Signaling Pathway Diagram
Stimuli-sensing Channels Pathway antibodies	Stimuli-sensing Channels Pathway Diagram
TRP Channels Pathway antibodies	TRP Channels Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-TRPC5 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>15 publications with TRPC5 and Cardiovascular Diseases
Nervous System Diseases Antibodies	>13 publications with TRPC5 and Nervous System Diseases
Hypertension Antibodies	>12 publications with TRPC5 and Hypertension
Brain Diseases Antibodies	>9 publications with TRPC5 and Brain Diseases
Inflammation Antibodies	>7 publications with TRPC5 and Inflammation
Pain Antibodies	>7 publications with TRPC5 and Pain
Neurologic Manifestations Antibodies	>5 publications with TRPC5 and Neurologic Manifestations
Kidney Diseases Antibodies	>4 publications with TRPC5 and Kidney Diseases
Lung Diseases Antibodies	>4 publications with TRPC5 and Lung Diseases
Seizures Antibodies	>3 publications with TRPC5 and Seizures

Organs/Tissues associated with anti-TRPC5 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>71 publications with TRPC5 and Brain
Placenta Antibodies	>2 publications with TRPC5 and Placenta