Mouse Anti-LGI1 Monoclonal Antibody – Cat# MBS801820

Western Blot analysis of Rat Brain Membrane showing detection of ~60 kDa LGI1 protein using Mouse Anti-LGI1 Monoclonal Antibody, Clone S283-7. Load: 10 ug. Primary Antibody: Mouse Anti-LGI1 Monoclonal Antibody at 1:1000 for 1 hour at RT. Secondary Antibody: Goat Anti-Mouse HRP at 1:200 for 1 hour at RT. Predicted/Observed Size: ~60 kDa.

LGI1 Antibody – Mouse Monoclonal

Name: LGI1 Antibody; Monoclonal; Mouse; Human/Rat/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS801820
Price: 575 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS801820

Background Info: Detects a 60 kDa protein corresponding to the molecular weight of LGI1.Scientific Background: The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other… More details

$575 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LGI1, Monoclonal Antibody

Full Product Name

LGI1 Antibody: PerCP

Product Gene Name

anti-Lgi1 antibody

Product Synonym Names

ADLTE; ADPAEF; ADPEAF; Epitempin 1; EPT; ETL1; IB1099; leucine rich glioma inactivated 1; OTTHUMP00000020121; OTTHUMP00000020122

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

S283-7

Host

Mouse

Species Reactivity

Human, Rat, Mouse

Form/Format

Protein G Purified

Concentration

1mg/ml (lot specific)

Preparation and Storage

-20 degree C

Matching Pairs

Unconjugated Antibody: LGI1 Clone #S283-7 (MBS800283)
PerCP Conjugated Antibody: LGI1 Clone #S283-7 (MBS801820)

Matching Pairs

Unconjugated Antibody: N/A (MBS801820)
PerCP Conjugated Antibody: LGI1 Clone #S283-7 (MBS801820)

Molecular Weight

– Da

3D Structure

ModBase 3D Structure for Q9JIA1

Conjugate

PerCP

Storage Buffer

PBS pH 7.4, 50% glycerol, 0.1% sodium azide

Product Categories/Family for anti-Lgi1 antibody

Ion Channels; Neuroscience

Applications Tested/Suitable for anti-Lgi1 antibody

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC)

Application Notes for anti-Lgi1 antibody

1:1000 WB

Product References and Citations for anti-Lgi1 antibody

1. Chernova O.B., Somerville R.P. and Cowell J.K. (1998) Oncogene. 17:2873-81. 2. Fialka F., et al. (2008) Oral Oncol. 3. Gu W., et al. (2005) Mol. Biol. Evol. 22:2209-16. 4. Fukata Y., et al. (2006) Science. 313:1792-5.

Other Notes

Small volumes of anti-Lgi1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Lgi1 purchase

MBS801820 is an antibody targeting Lgi1. Also known as LGI1 Antibody: PerCP. Reactive in Human, Rat, Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Lgi1. It may not necessarily be applicable to this product.

NCBI GI #

9938002

NCBI GeneID

56839

NCBI Accession #

NP_064674.1

UniProt Primary Accession #

Q9JIA1

UniProt Related Accession #

Q9JIA1

GenBank Nucleotide #

NM_020278.2

NCBI Official Full Name

leucine-rich glioma-inactivated protein 1

NCBI Official Synonym Full Names

leucine-rich repeat LGI family, member 1

NCBI Official Symbol

Lgi1

NCBI Official Synonym Symbols

BB130740

UniProt Protein Name

Leucine-rich glioma-inactivated protein 1

Protein Family

Leucine-rich glioma-inactivated protein

UniProt Gene Name

Lgi1

UniProt Entry Name

LGI1_MOUSE

NCBI Protein Information

leucine-rich glioma-inactivated protein 1; leucine-rich, glioma inactivated 1

UniProt Comments for Lgi1

LGI1: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. Defects in LGI1 are the cause of epilepsy, familial temporal lobe, type 1 (ETL1). A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular space; extracellular region; synapse; cell junction

Molecular Function: protein binding

Biological Process: axon guidance; positive regulation of cell growth; positive regulation of synaptic transmission; protein homooligomerization; neurite development

Research Articles on Lgi1

1. Lgi1 contains nuclear localization signal that mediates Lgi1 localization to cytoplasm and nucleus in CNS embryonic neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.