PINK1 Antibody – Mouse Monoclonal

PINK1: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Interats with PARK2. Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Other; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Mitochondrial; Other group; NKF2 family

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: mitochondrion; mitochondrial intermembrane space; cytosol; mitochondrial outer membrane; cytoskeleton; membrane; axon; perinuclear region of cytoplasm; cytoplasm; mitochondrial inner membrane; TORC2 complex; chromatin; nucleus; integral to mitochondrial outer membrane

Molecular Function: protein kinase B binding; protein serine/threonine kinase activity; protein binding; protease activator activity; protease binding; ubiquitin protein ligase binding; magnesium ion binding; kinase activity; ATP binding

Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of JNK cascade; mitochondrion organization and biogenesis; positive regulation of dopamine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein stabilization; positive regulation of translation; regulation of protein ubiquitination; activation of protein kinase B; positive regulation of synaptic transmission, dopaminergic; protein ubiquitination; protein amino acid phosphorylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of macroautophagy; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; regulation of mitochondrial membrane potential; positive regulation of ubiquitin-protein ligase activity; mitochondrion degradation; response to stress; regulation of protein complex assembly; positive regulation of transcription factor activity; response to oxidative stress; negative regulation of neuron apoptosis; positive regulation of protein amino acid phosphorylation; phosphorylation; regulation of hydrogen peroxide metabolic process

Disease: Parkinson Disease 6, Autosomal Recessive Early-onset