Mouse Anti-DLG2 Monoclonal Antibody – Cat# MBS802394

Western Blot analysis of Rat brain membrane lysate showing detection of Chapsyn-110 protein using Mouse Anti-Chapsyn-110 Monoclonal Antibody, Clone S18-30. Load: 15 ug. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Chapsyn-110 Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.

Chapsyn-110 (DLG2) Antibody – Mouse Monoclonal

Name: DLG2 Antibody; Monoclonal; Mouse; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS802394
Price: 550 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS802394

Background Info: Detects ~110kDa. No cross-reactivity against other MAGUK family members, PSD95, SAP97, SAP102, expressed in transfected cells.Scientific Background: Chapsyn-110, is a part of the membrane-associated putative guanylate kinase (MAGUK) family.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Chapsyn-110 (Dlg2), Monoclonal Antibody

Full Product Name

Chapsyn-110 Antibody: ATTO 390

Product Gene Name

anti-Dlg2 antibody

Product Synonym Names

PSD93; Chapsyn-110; MGC131811; PSD-93; Discs Large Homolog 2; DLG2; Postsynaptic density protein PSD-93; DLGH2; Channel-associated protein of synapse-110

Clonality

Monoclonal

Isotype

IgG1

Clone Number

S18-30

Host

Mouse

Species Reactivity

Human (weak), Mouse, Rat

Form/Format

Protein G Purified

Concentration

1mg/mL (lot specific)

Preparation and Storage

-20 degree C

Molecular Weight

97,486 Da

3D Structure

ModBase 3D Structure for Q63622

Conjugate

ATTO 390

Storage Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Product Categories/Family for anti-Dlg2 antibody

Neuroscience; Organelle Markers; Scaffolds

Applications Tested/Suitable for anti-Dlg2 antibody

Western (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Application Notes for anti-Dlg2 antibody

1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)

Product References and Citations for anti-Dlg2 antibody

1. Kim E., et al. (1996) Neuron. 17:103-113. 2. Godreau D., Neyroud N., Vranckx R. and Hatem S. (2004) Med Sci (Paris). 20(1): 84-88.

Other Notes

Small volumes of anti-Dlg2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Dlg2 purchase

MBS802394 is an antibody targeting Dlg2. Also known as Chapsyn-110 Antibody: ATTO 390. Reactive in Human (weak), Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Dlg2. It may not necessarily be applicable to this product.

NCBI GI #

11560113

NCBI GeneID

64053

NCBI Accession #

NP_071618.1

UniProt Primary Accession #

Q63622

UniProt Secondary Accession #

P70548; Q62939

UniProt Related Accession #

Q63622

GenBank Nucleotide #

NM_022282.1

NCBI Official Full Name

disks large homolog 2

NCBI Official Synonym Full Names

discs, large homolog 2 (Drosophila)

NCBI Official Symbol

Dlg2

NCBI Official Synonym Symbols

Dlgh2

UniProt Protein Name

Disks large homolog 2

UniProt Synonym Protein Names

Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93

Protein Family

Disks large

UniProt Gene Name

Dlg2

UniProt Synonym Gene Names

Dlgh2; Chapsyn-110

UniProt Entry Name

DLG2_RAT

NCBI Protein Information

disks large homolog 2; chapsyn-110; discs large homolog 2; synaptic density protein PSD-93; postsynaptic density protein PSD-93; channel-associated protein of synapse-110

NCBI Summary for Dlg2

membrane associated guanylate kinase localized at postsynaptic density (PSD); may function to maintain the structure of PSD by concentrating its components to the membrane area [RGD, Feb 2006]

UniProt Comments for Dlg2

PSD-93: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain. Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Belongs to the MAGUK family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; membrane; cell soma; basolateral plasma membrane; cytoplasm; postsynaptic density; dendrite; ionotropic glutamate receptor complex; cell junction

Molecular Function: protein C-terminus binding; ionotropic glutamate receptor binding; guanylate kinase activity; protein binding; protein heterodimerization activity; protein phosphatase binding; PDZ domain binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; synaptic transmission; neuronal ion channel clustering; sensory perception of pain; receptor clustering; nucleotide phosphorylation

Research Articles on Dlg2

1. Evidence supports PSD-93 as a new substrate of the synaptic species of ERK; ERK2 possesses the ability to interact with PSD-93 and phosphorylate PSD-93 at a specific site.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Dlg2 antibody

Products by Pathway	Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Wnt Signaling Pathway NetPath antibodies	Wnt Signaling Pathway NetPath Diagram

Diseases associated with anti-Dlg2 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>3 publications with Dlg2 and Carcinoma
Nervous System Diseases Antibodies	>3 publications with Dlg2 and Nervous System Diseases
Ovarian Neoplasms Antibodies	>2 publications with Dlg2 and Ovarian Neoplasms
Ovarian Diseases Antibodies	>2 publications with Dlg2 and Ovarian Diseases
Breast Neoplasms Antibodies	>2 publications with Dlg2 and Breast Neoplasms
Neoplasms, Experimental Antibodies	>2 publications with Dlg2 and Neoplasms, Experimental
Cognition Disorders Antibodies	>2 publications with Dlg2 and Cognition Disorders
Adenocarcinoma Antibodies	>1 publications with Dlg2 and Adenocarcinoma
Weight Loss Antibodies	>1 publications with Dlg2 and Weight Loss
Lung Neoplasms Antibodies	>1 publications with Dlg2 and Lung Neoplasms

Organs/Tissues associated with anti-Dlg2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>27 publications with Dlg2 and Brain