Neuroligin 3 (NLGN3) Antibody – Mouse Monoclonal

NLGN3: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Defects in NLGN3 may be the cause of susceptibility to autism X-linked type 1 (AUTSX1). AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN3 may be the cause of susceptibility to X- linked Asperger syndrome 1 (ASPGX1). ASPGX1 is considered to be a form of childhood autism. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Cellular Component: extracellular space; cell surface; integral to plasma membrane; endocytic vesicle; excitatory synapse; synapse; cell junction

Molecular Function: neurexin binding; receptor activity; cell adhesion molecule binding

Biological Process: regulation of synaptic transmission; receptor-mediated endocytosis; rhythmic synaptic transmission; regulation of synaptic transmission, glutamatergic; metabolic process; axon extension; neurological control of breathing; learning; social behavior; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; regulation of inhibitory postsynaptic membrane potential; synaptogenesis; adult behavior; synapse organization and biogenesis; oligodendrocyte differentiation; visual learning; neuron adhesion; cell adhesion; regulation of excitatory postsynaptic membrane potential