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Cavbeta2 (CACNB2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS802743

Background Info: Detects ~78 kDa. No cross reactivity against Cavbeta1, Cavbeta3, Cavbeta4Scientific Background: Cav Beat subunits are involved in the transport of the pore forming alpha1 subunit to the plasma membrane (3). They also shield an ER Retention… More details

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Product Overview

Product Name
Cavbeta2 (Cacnb2), Monoclonal Antibody
Full Product Name
CaVbeta2 Antibody: Alkaline Phosphatase
Product Gene Name
anti-Cacnb2 antibody
Product Synonym Names
Cacnlb2; cacnb2; Voltage-dependent L-type calcium channel subunit beta-2; CAB2
Clonality
Monoclonal
Isotype
IgG1
Clone Number
S8b-1
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Protein G Purified
Concentration
1mg/mL (lot specific)
Preparation and Storage
-20 degree C
Molecular Weight
68,066 Da
3D Structure
ModBase 3D Structure for Q8VGC3
Conjugate
Alkaline Phosphatase
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide

Product Categories/Family for anti-Cacnb2 antibody

Ion Channels; Neuroscience
Applications Tested/Suitable for anti-Cacnb2 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-Cacnb2 antibody
1ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)

Immunohistochemistry (IHC) of anti-Cacnb2 antibody

Immunohistochemistry analysis using Mouse Anti-Cav Beta2 Calcium Channel Monoclonal Antibody, Clone S8b-1. Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-Cav Beta2 Calcium Channel Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: All nuclei. Some nuclei also staining higher up in epidermis.
Mouse Anti-CACNB2 Monoclonal Antibody – Cat# MBS802743

Western Blot (WB) of anti-Cacnb2 antibody

Western Blot analysis of Human Cell line lysates showing detection of Cav Beta2 Calcium Channel protein using Mouse Anti-Cav Beta2 Calcium Channel Monoclonal Antibody, Clone S8b-1. Load: 15 ug. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Cav Beta2 Calcium Channel Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.
Mouse Anti-CACNB2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS802743

Immunocytochemistry/Immunofluorescence (ICC/IF) of anti-Cacnb2 antibody

Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Cav Beta2 Calcium Channel Monoclonal Antibody, Clone S8b-1. Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20 degree C. Primary Antibody: Mouse Anti-Cav Beta2 Calcium Channel Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: All cells positive. Bright dottiness located throughout cytoplasm and in nuclei.
Mouse Anti-CACNB2 Monoclonal Antibody, Immunocytochemistry/Immunofluorescence (ICC/IF) – Cat# MBS802743

Product References and Citations for anti-Cacnb2 antibody

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Dolphin A.C. (2003) J Bioenerg. Biomembr. 35: 599-620. 4. Bichet D., et al. (2000) Neuron. 25: 177-190. 5. Xie M., et al. (2007) J Cell Biol. 178(3): 489-502.

Other Notes

Small volumes of anti-Cacnb2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cacnb2 purchase

MBS802743 is an antibody targeting Cacnb2. Also known as CaVbeta2 Antibody: Alkaline Phosphatase. Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Cacnb2. It may not necessarily be applicable to this product.

NCBI GI #
16758716
NCBI GeneID
116600
NCBI Accession #
NP_446303
UniProt Primary Accession #
Q8VGC3
UniProt Secondary Accession #
Q811Q6; Q811Q7; Q91ZJ8; Q9QUU7
UniProt Related Accession #
Q8VGC3
GenBank Nucleotide #
NM_053851.1
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit beta-2
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, beta 2 subunit
NCBI Official Symbol
Cacnb2
NCBI Official Synonym Symbols
Cacnlb2
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit beta-2
UniProt Synonym Protein Names
Calcium channel voltage-dependent subunit beta 2
Protein Family
Voltage-dependent L-type calcium channel
UniProt Gene Name
Cacnb2
UniProt Synonym Gene Names
Cacnlb2; CAB2
UniProt Entry Name
CACB2_RAT
NCBI Protein Information
voltage-dependent L-type calcium channel subunit beta-2; CAB2; calcium channel voltage-dependent subunit beta 2

NCBI Summary for Cacnb2

auxillary subunit of the L-type Ca(2+) channel [RGD, Feb 2006]

UniProt Comments for Cacnb2

CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Cellular Component: voltage-gated calcium channel complex; sarcolemma

Molecular Function: voltage-gated calcium channel activity; protein domain specific binding; calcium channel regulator activity; high voltage-gated calcium channel activity; phosphoprotein binding; protein kinase binding

Biological Process: synaptic transmission; visual perception; calcium ion transport; positive regulation of calcium ion transport; neuromuscular junction development
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Research Articles on Cacnb2

1. analysis of how voltage-gated calcium channel beta2e-subunit N-terminal domain is tethered to the plasma membrane via electrostatic and hydrophobic interactions

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Cacnb2 antibody

 Reference Product  PubMed Publications
 Cacna1c antibody  >19 publications with Cacnb2 and Cacna1c
 Cacna1d antibody  >4 publications with Cacnb2 and Cacna1d
 Cacna1e antibody  >4 publications with Cacnb2 and Cacna1e
 Cacnb3 antibody  >3 publications with Cacnb2 and Cacnb3
 Cacna1a antibody  >3 publications with Cacnb2 and Cacna1a
 Cacnb1 antibody  >2 publications with Cacnb2 and Cacnb1
 Cacna1g antibody  >2 publications with Cacnb2 and Cacna1g

Pathways associated with anti-Cacnb2 antibody

 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway antibodies  Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram

Diseases associated with anti-Cacnb2 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >15 publications with Cacnb2 and Heart Diseases
 Nervous System Diseases Antibodies  >10 publications with Cacnb2 and Nervous System Diseases
 Brugada Syndrome 4 Antibodies  >4 publications with Cacnb2 and Brugada Syndrome 4
 Congenital Abnormalities Antibodies  >3 publications with Cacnb2 and Congenital Abnormalities
 Hypertrophy Antibodies  >2 publications with Cacnb2 and Hypertrophy
 Inflammation Antibodies  >2 publications with Cacnb2 and Inflammation
 Immune System Diseases Antibodies  >2 publications with Cacnb2 and Immune System Diseases
 Lung Neoplasms Antibodies  >1 publications with Cacnb2 and Lung Neoplasms
 Weight Loss Antibodies  >1 publications with Cacnb2 and Weight Loss
 Atrophy Antibodies  >1 publications with Cacnb2 and Atrophy

Organs/Tissues associated with anti-Cacnb2 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >24 publications with Cacnb2 and Heart
 Brain Antibodies  >13 publications with Cacnb2 and Brain
 Kidney Antibodies  >3 publications with Cacnb2 and Kidney
 Embryonic Tissue Antibodies  >2 publications with Cacnb2 and Embryonic Tissue
 Inner Ear Antibodies  >1 publications with Cacnb2 and Inner Ear
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