Glun1-NR1 (GRIN1) Antibody – Mouse Monoclonal

NMDAR1: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Channel, calcium

Cellular Component: cell surface; integral to plasma membrane; endoplasmic reticulum; cell; dendrite; postsynaptic density; dendritic spine; terminal button; excitatory synapse; N-methyl-D-aspartate selective glutamate receptor complex; postsynaptic membrane; synaptic vesicle; cell soma; membrane; cytoplasm; synapse; cell junction

Molecular Function: protein dimerization activity; voltage-gated cation channel activity; neurotransmitter binding; glutamate receptor binding; calcium channel activity; calcium ion binding; calmodulin binding; protein binding; enzyme binding; extracellular-glutamate-gated ion channel activity; glutamate binding; ionotropic glutamate receptor activity; protein heterodimerization activity; N-methyl-D-aspartate selective glutamate receptor activity; glycine binding; cation channel activity; receptor binding

Biological Process: regulation of long-term neuronal synaptic plasticity; startle response; male mating behavior; prepulse inhibition; adult locomotory behavior; positive regulation of apoptosis; regulation of dendrite morphogenesis; rhythmic process; regulation of synaptic plasticity; response to morphine; regulation of axonogenesis; sensory perception of pain; response to organic cyclic substance; calcium ion homeostasis; regulation of respiratory gaseous exchange; learning and/or memory; calcium ion transport; conditioned taste aversion; regulation of neuron apoptosis; visual learning; negative regulation of neuron apoptosis; cation transport; protein tetramerization; associative learning; synaptic transmission, glutamatergic; neuromuscular process; response to amphetamine; social behavior; learning; respiratory gaseous exchange; pons maturation; memory; cellular calcium ion homeostasis; regulation of membrane potential; response to ethanol; suckling behavior; regulation of synaptogenesis; long-term memory; olfactory learning; propylene metabolic process; ionotropic glutamate receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; response to calcium ion; regulation of excitatory postsynaptic membrane potential; regulation of neuronal synaptic plasticity; response to amine stimulus