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TRPC7 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS804361

Background Info: Detects ~100kDa.Scientific Background: Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a non-selective cation channel that is directly activated by DAG. TrpC7 shows constitutive activity and… More details

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Product Overview

Product Name
TrpC7, Monoclonal Antibody
Full Product Name
TrpC7 Antibody: Alkaline Phosphatase
Product Gene Name
anti-TRPC7 antibody
Product Synonym Names
TRP7; KNP3; TRPM2; transient receptor potential cation channel subfamily C member 7
Clonality
Monoclonal
Isotype
IgG1
Clone Number
S64A-36
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Protein G Purified
Concentration
1mg/mL (lot specific)
Preparation and Storage
-20 degree C
Molecular Weight
92,429 Da
3D Structure
ModBase 3D Structure for Q9HCX4
Conjugate
Alkaline Phosphatase
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide

Product Categories/Family for anti-TRPC7 antibody

Ion Channels; Neuroscience
Applications Tested/Suitable for anti-TRPC7 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TRPC7 antibody
1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)

Immunohistochemistry (IHC) of anti-TRPC7 antibody

Immunohistochemistry analysis using Mouse Anti-TrpC7 Monoclonal Antibody, Clone S64A-36. Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-TrpC7 Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Everything.
Mouse Anti-TRPC7 Monoclonal Antibody – Cat# MBS804361

Western Blot (WB) of anti-TRPC7 antibody

Western Blot analysis of Rat brain membrane lysate showing detection of TrpC7 protein using Mouse Anti-TrpC7 Monoclonal Antibody, Clone S64A-36. Load: 15 ug. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-TrpC7 Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.
Mouse Anti-TRPC7 Monoclonal Antibody, Western Blot (WB) – Cat# MBS804361

Immunocytochemistry/Immunofluorescence (ICC/IF) of anti-TRPC7 antibody

Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-TrpC7 Monoclonal Antibody, Clone S64A-36. Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20 degree C. Primary Antibody: Mouse Anti-TrpC7 Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Nuclear staining .
Mouse Anti-TRPC7 Monoclonal Antibody, Immunocytochemistry/Immunofluorescence (ICC/IF) – Cat# MBS804361

Product References and Citations for anti-TRPC7 antibody

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Numaga T., Wakamori M., and Mori Y. (2007) Handb Exp Pharmacol. 179: 143-151. 4. Satoh S., et al. (2007) Mol Cell Biochem. 294(1-2): 205-215.

Other Notes

Small volumes of anti-TRPC7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRPC7 purchase

MBS804361 is an antibody targeting TRPC7. Also known as TrpC7 Antibody: Alkaline Phosphatase. Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TRPC7. It may not necessarily be applicable to this product.

NCBI GI #
9966865
NCBI GeneID
57113
NCBI Accession #
NP_065122.1
UniProt Primary Accession #
Q9HCX4
UniProt Secondary Accession #
Q70T26; Q8IWP7; A1A4Z4; F5H5U9
UniProt Related Accession #
Q9HCX4
GenBank Nucleotide #
NM_020389.2
NCBI Official Full Name
short transient receptor potential channel 7 isoform 1
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily C, member 7
NCBI Official Symbol
TRPC7
NCBI Official Synonym Symbols
TRP7
UniProt Protein Name
Short transient receptor potential channel 7
UniProt Synonym Protein Names
Transient receptor protein 7; TRP-7; hTRP7
Protein Family
Short transient receptor potential channel
UniProt Gene Name
TRPC7
UniProt Synonym Gene Names
TRP7; TrpC7; TRP-7; hTRP7
UniProt Entry Name
TRPC7_HUMAN
NCBI Protein Information
short transient receptor potential channel 7; TRP-7; hTRP7; transient receptor protein 7; putative capacitative calcium channel; likley ortholog of mouse transient receptor potential cation channel, subfamily C, member 7

UniProt Comments for TRPC7

TRPC7: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cis-Golgi network; perinuclear region of cytoplasm; integral to membrane; plasma membrane; nuclear envelope

Molecular Function: protein binding; calcium channel activity

Biological Process: platelet activation; axon guidance; manganese ion transport; blood coagulation; transmembrane transport
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Research Articles on TRPC7

1. Phosphorylation of transient receptor potential cation channel subfamily C member 7 significantly suppressed carbachol-induced calcium influx and CREB phosphorylation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRPC7 antibody

 Reference Product  PubMed Publications
 TRPC3 antibody  >78 publications with TRPC7 and TRPC3
 TRPC6 antibody  >73 publications with TRPC7 and TRPC6

Pathways associated with anti-TRPC7 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Effects Of PIP2 Hydrolysis Pathway antibodies  Effects Of PIP2 Hydrolysis Pathway Diagram
 Elevation Of Cytosolic Ca2+ Levels Pathway antibodies  Elevation Of Cytosolic Ca2+ Levels Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Netrin-1 Signaling Pathway antibodies  Netrin-1 Signaling Pathway Diagram

Diseases associated with anti-TRPC7 antibody

 Disease Name  Pubmed Publications
 Myocardial Infarction Antibodies  >3 publications with TRPC7 and Myocardial Infarction
 Edema Antibodies  >1 publications with TRPC7 and Edema
 Seizures Antibodies  >1 publications with TRPC7 and Seizures
 Hyperplasia Antibodies  >1 publications with TRPC7 and Hyperplasia
 Kidney Diseases Antibodies  >1 publications with TRPC7 and Kidney Diseases
 Inflammation Antibodies  >1 publications with TRPC7 and Inflammation
 Pancreatic Neoplasms Antibodies  >1 publications with TRPC7 and Pancreatic Neoplasms

Organs/Tissues associated with anti-TRPC7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >24 publications with TRPC7 and Brain
 Pancreas Antibodies  >1 publications with TRPC7 and Pancreas
 Testis Antibodies  >1 publications with TRPC7 and Testis
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