Glua1/Glur1 Glutamate Receptor (GRIA1) Antibody – Mouse Monoclonal

GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation.

Protein type: Channel, ligand-gated; Membrane protein, integral; Channel, calcium; Membrane protein, multi-pass

Cellular Component: endoplasmic reticulum membrane; neuron projection; protein complex; cell surface; endoplasmic reticulum; postsynaptic density; early endosome; dendrite; integral to membrane; dendritic spine; excitatory synapse; cytosol; asymmetric synapse; postsynaptic membrane; synaptic vesicle; recycling endosome; cell soma; membrane; plasma membrane; ionotropic glutamate receptor complex; synapse; dendritic shaft; neuromuscular junction; cell junction

Molecular Function: protein domain specific binding; identical protein binding; protein homodimerization activity; myosin V binding; G-protein alpha-subunit binding; G-protein beta-subunit binding; protein kinase binding; PDZ domain binding; small GTPase binding; protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; protein kinase A binding; beta-2 adrenergic receptor binding; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; adenylate cyclase binding

Biological Process: response to drug; regulation of synaptic transmission; synaptic transmission, glutamatergic; response to peptide hormone stimulus; response to toxin; response to lithium ion; response to arsenic; generation of action potential; regulation of synaptic plasticity; response to cocaine; response to organic cyclic substance; positive regulation of synaptic transmission; response to estradiol stimulus; synaptic transmission; long-term memory; ionotropic glutamate receptor signaling pathway; spinal cord development; receptor internalization; regulation of receptor recycling; response to electrical stimulus; positive regulation of membrane potential