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Gaba(a) Receptor Beta1 (GABRB1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS804532

Background Info: Detects ~55kDa. No cross-reactivity against GABA-A-R-Beta 2 or -Beta3.Scientific Background: The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar… More details

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Product Overview

Product Name
GABA(A) Receptor Beta1 (Gabrb1), Monoclonal Antibody
Full Product Name
GABA-A Receptor Beta1 Antibody: FITC
Product Gene Name
anti-Gabrb1 antibody
Product Synonym Names
Gabrb-1; Gabrb1; AW061132
Clonality
Monoclonal
Isotype
IgG1
Clone Number
S96-55
Host
Mouse
Species Reactivity
Mouse, Human, Rat
Form/Format
Protein G Purified
Concentration
1mg/mL (lot specific)
Preparation and Storage
-20 degree C
Molecular Weight
54,100 Da
3D Structure
ModBase 3D Structure for P50571
Conjugate
FITC
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide

Product Categories/Family for anti-Gabrb1 antibody

Ion Channels; Neuroscience
Applications Tested/Suitable for anti-Gabrb1 antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-Gabrb1 antibody
1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)

Immunocytochemistry/Immunofluorescence (ICC/IF) of anti-Gabrb1 antibody

Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-GABA A Receptor Monoclonal Antibody, Clone S96-55. Tissue: HaCaT cells. Species: Human. Fixation: Cold 100% methanol for 10 minutes at -20 degree C. Primary Antibody: Mouse Anti-GABA A Receptor Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Positive.
Mouse Anti-GABRB1 Monoclonal Antibody – Cat# MBS804532

Western Blot (WB) of anti-Gabrb1 antibody

Western Blot analysis of Human Cell line lysates showing detection of GABA A Receptor protein using Mouse Anti-GABA A Receptor Monoclonal Antibody, Clone S96-55. Load: 15 ug. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-GABA A Receptor Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.
Mouse Anti-GABRB1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS804532

Immunohistochemistry (IHC) of anti-Gabrb1 antibody

Immunohistochemistry analysis using Mouse Anti-GABA A Receptor Monoclonal Antibody, Clone S96-55. Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-GABA A Receptor Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dermal staining.
Mouse Anti-GABRB1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS804532

Product References and Citations for anti-Gabrb1 antibody

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136. 4. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569- 602.

Other Notes

Small volumes of anti-Gabrb1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gabrb1 purchase

MBS804532 is an antibody targeting Gabrb1. Also known as GABA-A Receptor Beta1 Antibody: FITC. Reactive in Mouse, Human, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Gabrb1. It may not necessarily be applicable to this product.

NCBI GI #
6679907
NCBI GeneID
14400
NCBI Accession #
NP_032095.1
UniProt Primary Accession #
P50571
UniProt Related Accession #
P50571
GenBank Nucleotide #
NM_008069.4
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit beta-1
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
NCBI Official Symbol
Gabrb1
NCBI Official Synonym Symbols
Gabrb-1; AW061132; B230208N19Rik
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit beta-1
UniProt Synonym Protein Names
GABA(A) receptor subunit beta-1
Protein Family
Gamma-aminobutyric acid receptor
UniProt Gene Name
Gabrb1
UniProt Entry Name
GBRB1_MOUSE
NCBI Protein Information
gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor subunit beta-1; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1

UniProt Comments for Gabrb1

GABRB1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily.

Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel; Transporter; Channel, chloride

Cellular Component: postsynaptic membrane; membrane; integral to plasma membrane; dendrite; cytoplasm; plasma membrane; integral to membrane; nuclear envelope; synapse; nucleus; cell junction; receptor complex

Molecular Function: chloride channel activity; GABA-A receptor activity; anion channel activity; ion channel activity; GABA receptor binding; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity

Biological Process: transport; response to toxin; ion transport; chloride transport; signal transduction; anion transport
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Research Articles on Gabrb1

1. Heritable preference for ethanol results from a dominant mutation L285R; P228H also causes high ethanol consumption

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Gabrb1 antibody

 Reference Product  PubMed Publications
 Gabra4 antibody  >14 publications with Gabrb1 and Gabra4
 Gabra2 antibody  >11 publications with Gabrb1 and Gabra2
 Gabrb3 antibody  >10 publications with Gabrb1 and Gabrb3
 Gabra5 antibody  >9 publications with Gabrb1 and Gabra5
 Gabrb2 antibody  >9 publications with Gabrb1 and Gabrb2
 Gabra1 antibody  >7 publications with Gabrb1 and Gabra1
 Gabrg2 antibody  >4 publications with Gabrb1 and Gabrg2
 Gabra6 antibody  >3 publications with Gabrb1 and Gabra6
 Gabrg3 antibody  >2 publications with Gabrb1 and Gabrg3
 Gabra3 antibody  >1 publications with Gabrb1 and Gabra3

Pathways associated with anti-Gabrb1 antibody

 Products by Pathway  Pathway Diagram
 GABA A Receptor Activation Pathway antibodies  GABA A Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-Gabrb1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >8 publications with Gabrb1 and Nervous System Diseases
 Anxiety Disorders Antibodies  >4 publications with Gabrb1 and Anxiety Disorders
 Brain Diseases Antibodies  >4 publications with Gabrb1 and Brain Diseases
 Central Nervous System Diseases Antibodies  >4 publications with Gabrb1 and Central Nervous System Diseases
 Autistic Disorder Antibodies  >4 publications with Gabrb1 and Autistic Disorder
 Cognition Disorders Antibodies  >3 publications with Gabrb1 and Cognition Disorders
 Movement Disorders Antibodies  >2 publications with Gabrb1 and Movement Disorders
 Epilepsy Antibodies  >2 publications with Gabrb1 and Epilepsy
 Inflammation Antibodies  >1 publications with Gabrb1 and Inflammation
 Memory Disorders Antibodies  >1 publications with Gabrb1 and Memory Disorders

Organs/Tissues associated with anti-Gabrb1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with Gabrb1 and Brain
 Embryonic Tissue Antibodies  >1 publications with Gabrb1 and Embryonic Tissue
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