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TASK1 Potassium Channel (KCNK3) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS804886

Background Info: Detects a 50 kDa protein. Does not cross-react with TASK3.Scientific Background: K+ channels are divided into three subclasses reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the… More details

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Product Overview

Online Datasheet in PDF
Product Name
TASK1 Potassium Channel (Kcnk3), Monoclonal Antibody
Full Product Name
TASK1 Potassium Channel Antibody: ATTO 488
Product Gene Name
anti-Kcnk3 antibody
Product Synonym Names
Potassium channel subfamily K member 3; KCNK3; Acid sensitive potassium channel protein TASK 1; Cardiac two pore background K(+) channel; cTBAK 1; K2p3.1; KCNK9; OAT1; potassium channel subfamily K member 3; rTASK; TASK 1; TBAK1
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
S374-48
Host
Mouse
Species Reactivity
Mouse, Rat
Form/Format
Protein G Purified
Concentration
1mg/mL (lot specific)
Preparation and Storage
-20 degree C
Matching Pairs
Unconjugated Antibody: N/A (MBS804886)
ATTO 488 Conjugated Antibody: TASK1 Potassium Channel Clone #S374-48 (MBS804886)
Molecular Weight
45,276 Da
3D Structure
ModBase 3D Structure for O54912
Conjugate
ATTO 488
Storage Buffer
PBS pH 7.4, 50% glycerol, 0.1% sodium azide

Product Categories/Family for anti-Kcnk3 antibody

Neuroscience
Applications Tested/Suitable for anti-Kcnk3 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC)
Application Notes for anti-Kcnk3 antibody
1:1000 WB

Immunocytochemistry (ICC) of anti-Kcnk3 antibody

Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-TASK1 Potassium Channel Monoclonal Antibody, Clone S374-48 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-TASK1 Potassium Channel Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) TASK1 Potassium Channel Antibody. (D) Composite.
Mouse Anti-KCNK3 Monoclonal Antibody – Cat# MBS804886

Western Blot (WB) of anti-Kcnk3 antibody

Western Blot analysis of Rat Brain Membrane showing detection of ~50 kDa TASK1 Potassium Channel protein using Mouse Anti-TASK1 Potassium Channel Monoclonal Antibody, Clone S374-48 . Lane 1: Molecular Weight Ladder (MW). Lane 2: Rat brain membrane. Load: 15 ug. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-TASK1 Potassium Channel Monoclonal Antibody at 1:1000 for 16 hours at 4 degree C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~50 kDa.
Mouse Anti-KCNK3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS804886

Other Notes

Small volumes of anti-Kcnk3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Kcnk3 purchase

MBS804886 is an antibody targeting Kcnk3. Also known as TASK1 Potassium Channel Antibody: ATTO 488. Reactive in Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Kcnk3. It may not necessarily be applicable to this product.

NCBI GI #
15431283
NCBI GeneID
29553
NCBI Accession #
NP_203694.1
UniProt Primary Accession #
O54912
UniProt Related Accession #
O54912
GenBank Nucleotide #
NM_033376.1
NCBI Official Full Name
potassium channel subfamily K member 3
NCBI Official Synonym Full Names
potassium channel, subfamily K, member 3
NCBI Official Symbol
Kcnk3
NCBI Official Synonym Symbols
rTASK; Task-1
UniProt Protein Name
Potassium channel subfamily K member 3
UniProt Synonym Protein Names
Acid-sensitive potassium channel protein TASK-1; TWIK-related acid-sensitive K(+) channel 1; Two pore potassium channel KT3.1; Two pore K(+) channel KT3.1
Protein Family
Potassium channel subfamily
UniProt Gene Name
Kcnk3
UniProt Synonym Gene Names
Task; Task1; Two pore K(+) channel KT3.1
UniProt Entry Name
KCNK3_RAT
NCBI Protein Information
potassium channel subfamily K member 3; two pore K(+) channel KT3.1; two pore potassium channel KT3.1; TWIK-related acid-sensitive K+ channel; TWIK-related acid-sensitive K(+) channel 1; acid-sensitive potassium channel protein TASK-1

NCBI Summary for Kcnk3

a TWIK-related acid-sensitive K+ channel; functions as an open rectifier baseline potassium channel [RGD, Feb 2006]

UniProt Comments for Kcnk3

KCNK3: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein C-terminus binding; protein binding; protein homodimerization activity; open rectifier potassium channel activity; protein heterodimerization activity; potassium ion leak channel activity; ion channel activity

Biological Process: response to drug; reduction of cytosolic calcium ion concentration; brain development
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Research Articles on Kcnk3

1. Data indicate that Gja1, Cav3 and Kcnk3 were up-regulated and Hcn2 was down-regulated in hearts of exercise trained Goto-Kakizaki (GK) type 2 diabetic rat compared to sedentary GK controls.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Kcnk3 antibody

 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 TWIK-releated Acid-sensitive K+ Channel (TASK) Pathway antibodies  TWIK-releated Acid-sensitive K+ Channel (TASK) Pathway Diagram
 Tandem Pore Domain Potassium Channels Pathway antibodies  Tandem Pore Domain Potassium Channels Pathway Diagram

Diseases associated with anti-Kcnk3 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >13 publications with Kcnk3 and Hypertension
 Pain Antibodies  >7 publications with Kcnk3 and Pain
 Lung Diseases Antibodies  >5 publications with Kcnk3 and Lung Diseases
 Nervous System Diseases Antibodies  >5 publications with Kcnk3 and Nervous System Diseases
 Disease Models, Animal Antibodies  >5 publications with Kcnk3 and Disease Models, Animal
 Central Nervous System Diseases Antibodies  >4 publications with Kcnk3 and Central Nervous System Diseases
 Inflammation Antibodies  >3 publications with Kcnk3 and Inflammation
 Stroke Antibodies  >3 publications with Kcnk3 and Stroke
 Heart Diseases Antibodies  >3 publications with Kcnk3 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >1 publications with Kcnk3 and Arrhythmias, Cardiac

Organs/Tissues associated with anti-Kcnk3 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >29 publications with Kcnk3 and Nerve
 Brain Antibodies  >11 publications with Kcnk3 and Brain
 Heart Antibodies  >10 publications with Kcnk3 and Heart
 Ovary Antibodies  >2 publications with Kcnk3 and Ovary
 Adipose Tissue Antibodies  >1 publications with Kcnk3 and Adipose Tissue
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