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Aquaporin 1 (AQP1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS805150

Background Info: Detects ~28.5kDa. May detect larger glycosylated bands ~35-50kDa.Scientific Background: Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels,… More details

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Product Overview

Online Datasheet in PDF
Product Name
Aquaporin 1 (Aqp1), Polyclonal Antibody
Full Product Name
Aquaporin 1 Antibody: RPE
Product Gene Name
anti-Aqp1 antibody
Product Synonym Names
AQP1; AQP 1; AQP CHIP; AQP-1; AQP1; AQP1_HUMAN; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; Channel forming integral protein 28kDa; Channel like integral membrane protein 28 kDa; CHIP 28; CHIP28; CO; Colton blood group; Growth factor induced delayed early response protein; MGC26324; Urine water channel; Water channel protein CHIP 29; Water channel protein CHIP29; Water channel protein for red blood cells and kidney proximal tubule
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Affinity Purified
Concentration
1mg/mL (lot specific)
Preparation and Storage
4 degree C
Matching Pairs
Unconjugated Antibody: N/A (MBS805150)
RPE Conjugated Antibody: Aquaporin 1 (MBS805150)
Matching Pairs
Unconjugated Antibody: Aquaporin 1 (MBS806833)
RPE Conjugated Antibody: Aquaporin 1 (MBS805150)
Molecular Weight
28,857 Da
3D Structure
ModBase 3D Structure for P29975
Conjugate
RPE

Product Categories/Family for anti-Aqp1 antibody

Ion Channels and Transporters
Applications Tested/Suitable for anti-Aqp1 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-Aqp1 antibody
WB 1:1000-4000, IF: 1:200-400

Immunohistochemistry (IHC) of anti-Aqp1 antibody

Immunohistochemistry analysis using Rabbit Anti-Aquaporin 1 Polyclonal Antibody (SPC-502). Tissue: kidney tissue. Species: Rat. Fixation: 4% paraformaldehyde-lysine-periodate. Primary Antibody: Rabbit Anti-Aquaporin 1 Polyclonal Antibody (SPC-502) at 1:200 for 75 min at RT. Secondary Antibody: FITC Goat Anti-Rabbit (green) for 1 hour at RT. 4 um cryostat sections.
Rabbit Anti-AQP1 Polyclonal Antibody – Cat# MBS805150

Western Blot (WB) of anti-Aqp1 antibody

Western blot analysis of Rat kidney inner medullary homogenates showing detection of Aquaporin 1 protein using Rabbit Anti-Aquaporin 1 Polyclonal Antibody (SPC-502). Primary Antibody: Rabbit Anti-Aquaporin 1 Polyclonal Antibody (SPC-502) at 1:2000. Showing glycosylated and non-glycosylated bands.
Rabbit Anti-AQP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS805150

Product References and Citations for anti-Aqp1 antibody

1. Gonen T., Walz T. (2006) Q. Rev. Biophys. 39(4): 361-396. 2. Knepper M.A. (1994) Proc Natl. Acad Sci. USA. 91(14): 6255-6258. 3. www.vivo.colostate.edu/hbooks/molecules/aqu aporins.html

Other Notes

Small volumes of anti-Aqp1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Aqp1 purchase

MBS805150 is an antibody targeting Aqp1. Also known as Aquaporin 1 Antibody: RPE. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Aqp1. It may not necessarily be applicable to this product.

NCBI GI #
6978527
NCBI GeneID
25240
NCBI Accession #
NP_036910.1
UniProt Primary Accession #
P29975
UniProt Secondary Accession #
Q5EB50; Q7TN36
UniProt Related Accession #
P29975
GenBank Nucleotide #
NM_012778.1
NCBI Official Full Name
aquaporin-1
NCBI Official Synonym Full Names
aquaporin 1
NCBI Official Symbol
Aqp1
NCBI Official Synonym Symbols
CHIP28
UniProt Protein Name
Aquaporin-1
UniProt Synonym Protein Names
Aquaporin-CHIP; Water channel protein for red blood cells and kidney proximal tubule
Protein Family
Aquaporin
UniProt Gene Name
Aqp1
UniProt Synonym Gene Names
Chip28; AQP-1
UniProt Entry Name
AQP1_RAT
NCBI Protein Information
aquaporin-1; AQP-1; aquaporin-CHIP; Aquaporin 1 (aquaporin channel forming integral protein 28 (CHIP)); water channel protein for red blood cells and kidney proximal tubule

NCBI Summary for Aqp1

integral membrane protein that is a major water transport molecule in the kidney proximal tubule and red blood cells [RGD, Feb 2006]

UniProt Comments for Aqp1

AQP1: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Belongs to the MIP/aquaporin (TC 1.A.8) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family

Cellular Component: neuron projection; nuclear membrane; basolateral plasma membrane; cell; brush border membrane; integral to plasma membrane; integral to membrane; membrane; axon; apical part of cell; apical plasma membrane; cytoplasm; basal plasma membrane; plasma membrane; nerve terminal; nucleus; sarcolemma; brush border

Molecular Function: protein binding; potassium channel activity; ephrin receptor binding; water transporter activity; ammonium transmembrane transporter activity; intracellular cGMP activated cation channel activity; glycerol transmembrane transporter activity; potassium ion transmembrane transporter activity; transmembrane transporter activity; nitric oxide transporter activity; water channel activity; glycerol channel activity

Biological Process: glycerol transport; cGMP biosynthetic process; cerebrospinal fluid secretion; wound healing; carbon dioxide transport; water transport; response to hormone stimulus; negative regulation of caspase activity; pancreatic juice secretion; sensory perception of pain; positive regulation of saliva secretion; water homeostasis; odontogenesis; positive regulation of fibroblast proliferation; nitric oxide transport; hyperosmotic salinity response; multicellular organismal water homeostasis; cellular homeostasis; lateral ventricle development; lipid digestion; potassium ion transport; secretion by cell; response to drug; cellular water homeostasis; secretory granule organization and biogenesis; glomerular filtration; ammonium transport; hyperosmotic response; renal water transport; positive regulation of angiogenesis; camera-type eye morphogenesis; response to estrogen stimulus; adrenocorticotropin hormone secretion; establishment and/or maintenance of actin cytoskeleton polarity; cell volume homeostasis; positive regulation of cell migration; negative regulation of apoptosis
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Research Articles on Aqp1

1. Aqp1 enhances Bone marrow mesenchymal stem cell migration ability mainly through the focal adhesion kinase pathway and partially through the beta-catenin pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Aqp1 antibody

 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway antibodies  Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway Diagram
 Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway antibodies  Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 O2/CO2 Exchange In Erythrocytes Pathway antibodies  O2/CO2 Exchange In Erythrocytes Pathway Diagram
 Passive Transport By Aquaporins Pathway antibodies  Passive Transport By Aquaporins Pathway Diagram
 Proximal Tubule Bicarbonate Reclamation Pathway antibodies  Proximal Tubule Bicarbonate Reclamation Pathway Diagram
 Proximal Tubule Bicarbonate Reclamation Pathway antibodies  Proximal Tubule Bicarbonate Reclamation Pathway Diagram

Diseases associated with anti-Aqp1 antibody

 Disease Name  Pubmed Publications
 Edema Antibodies  >157 publications with Aqp1 and Edema
 Kidney Diseases Antibodies  >125 publications with Aqp1 and Kidney Diseases
 Nervous System Diseases Antibodies  >100 publications with Aqp1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >97 publications with Aqp1 and Disease Models, Animal
 Lung Diseases Antibodies  >53 publications with Aqp1 and Lung Diseases
 Carcinoma Antibodies  >47 publications with Aqp1 and Carcinoma
 Pulmonary Edema Antibodies  >40 publications with Aqp1 and Pulmonary Edema
 Inflammation Antibodies  >36 publications with Aqp1 and Inflammation
 Fibrosis Antibodies  >36 publications with Aqp1 and Fibrosis
 Hypertension Antibodies  >28 publications with Aqp1 and Hypertension

Organs/Tissues associated with anti-Aqp1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >384 publications with Aqp1 and Kidney
 Brain Antibodies  >197 publications with Aqp1 and Brain
 Lung Antibodies  >149 publications with Aqp1 and Lung
 Eye Antibodies  >139 publications with Aqp1 and Eye
 Heart Antibodies  >56 publications with Aqp1 and Heart
 Artery Antibodies  >42 publications with Aqp1 and Artery
 Embryonic Tissue Antibodies  >35 publications with Aqp1 and Embryonic Tissue
 Placenta Antibodies  >18 publications with Aqp1 and Placenta
 Connective Tissue Antibodies  >17 publications with Aqp1 and Connective Tissue
 Ovary Antibodies  >15 publications with Aqp1 and Ovary
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