SOD (Mn) (SOD2) Antibody – Rabbit Polyclonal

SOD2: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; EC 1.15.1.1; Oxidoreductase

Cellular Component: mitochondrion; cytoplasm; mitochondrial inner membrane; intracellular; myelin sheath

Molecular Function: identical protein binding; protein binding; DNA binding; manganese ion binding; superoxide dismutase activity; oxygen binding

Biological Process: positive regulation of nitric oxide biosynthetic process; heart development; response to lipopolysaccharide; protein homotetramerization; post-embryonic development; response to selenium ion; glutathione metabolic process; regulation of mitochondrial membrane potential; negative regulation of neuron apoptosis; response to electrical stimulus; response to drug; mitochondrion organization and biogenesis; erythrophore differentiation; release of cytochrome c from mitochondria; negative regulation of fat cell differentiation; response to manganese ion; regulation of transcription from RNA polymerase II promoter; iron ion homeostasis; response to reactive oxygen species; DNA damage response, signal transduction resulting in induction of apoptosis; age-dependent response to reactive oxygen species; response to zinc ion; negative regulation of fibroblast proliferation; hydrogen peroxide metabolic process; neuron development; response to activity; response to oxidative stress; superoxide release; negative regulation of apoptosis; oxygen homeostasis; removal of superoxide radicals; locomotory behavior; response to L-ascorbic acid; vasodilation; age-dependent response to oxidative stress; negative regulation of cell proliferation; apoptotic mitochondrial changes; response to radiation; sensory perception of sound; acetylcholine vasodilation involved in regulation of systemic arterial blood pressure; regulation of catalytic activity; regulation of blood pressure; response to gamma radiation; hemopoiesis; response to axon injury; protein homooligomerization; aging; response to nutrient levels; response to superoxide; superoxide metabolic process; liver development; response to silicon dioxide; response to cadmium ion; response to hyperoxia; response to hydrogen peroxide; detection of oxygen; response to hypoxia; response to cold; induction of apoptosis by oxidative stress; hydrogen peroxide biosynthetic process