Acetylated Lysine Antibody – Rabbit Polyclonal

Background Info: Detects proteins containing acetylated lysine residues in SDS PAGE immunoblots.

Scientific Background: Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine Nepsilon-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization (3). The regulation of protein acetylation status is impaired in the pathologies of cancer and polyglutamine diseases (4), and HDACs have become promising targets for anti-cancer drugs currently in development (5).

1. Yang XJ. (2005). Oncogene. 24:1653-1662. 2. Hassig, C.A. and Schreiber, S.L. (1997). Curr. Opin. Chem. Biol. 1(3): 300-308. 3. Yang XJ. (2004). Bioessays 26:1076-1087. 4. Hughes, R.E. (2002). Curr. Biol. 12: R141-R143. 5. Vigushin, D.M. and Coombes, R.C. (2004). Curr. Cancer Drug Targets 4: 205-218. 6. Chan, H.M. et al. (2001). Nat. Cell Biol. 3: 667-. 674. 7. Martinez-Balbas, M.A. et al. (2000). EMBO J. 19: 662-671.
1. Ishiguro, K., Ando, T., Maeda, O., Watanabe, O. and Goto, H. (2011). Cutting Edge: Tubulin α Functions as an Adaptor in NFAT–Importin β Interaction. J Immunol. 186 (5), 2710-2713. doi: 10.4049/jimmunol.1003322

Small volumes of anti-Acetylated Lysine antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS805679 is an antibody targeting Acetylated Lysine. Also known as Acetylated Lysine Antibody. Reactive in Acetylated lysine residues. No reaction to non-acetylated proteins.. Host: Rabbit.