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Amyloid Fibrils (Oc) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS805797

Function: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to… More details

$555 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Amyloid Fibrils (OC), Polyclonal Antibody
Full Product Name
Amyloid Fibrils (OC) Antibody: Biotin
Rabbit Anti-Human Amyloid Fibrils (OC) Antibody Polyclonal
Product Synonym Names
OC Antibody, Fibrils Antibody, Amyloid Oligomer ars Antibody, All Antibody, Amyloid beta A4 protein Antibody, ABPP Antibody, APPI Antibody, Alzheimer disease amyloid protein Antibody, Cerebral vascular amyloid peptide Antibody, PreA4 Antibody, Protease nexin-II Antibody, APP Antibody, A4 Antibody, AD Antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 50% glycerol, 0.09% sodium azide
Purity/Purification
Protein A Purified
Specificity
Recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrililar oligomers or natively folded proteins. Expected to detect in Mouse and Rat based on species homology.
Preparation and Storage
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
Matching Pairs
Unconjugated Antibody: N/A (MBS805797)
Biotin Conjugated Antibody: Amyloid Fibrils (OC) (MBS805797)
Matching Pairs
Unconjugated Antibody: Amyloid Fibrils (OC) (MBS806705)
Biotin Conjugated Antibody: Amyloid Fibrils (OC) (MBS805797)
Conjugate
Biotin
Certificate of Analysis
A 1:1000 dilution of MBS805797 was sufficient for detection of amyloid fibrils on PVDF membranes using transferred fibrils by colorimetric dot blot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Immunogen
Fibrils prepared from human amyloid beta 42 peptide
Research Area(s)
Neuroscience; Cell Signaling; Cardiovascular System; Blood; Neurodegenertation
Cellular Localization
Membrane

Product Categories/Family for anti-Amyloid Fibrils (OC) antibody

Neuroscience
Applications Tested/Suitable for anti-Amyloid Fibrils (OC) antibody
Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB), Dot Blot (DB), Immunofluorescence (IF)
Application Notes for anti-Amyloid Fibrils (OC) antibody
WB (1:1000)
IHC (1:100)
optimal dilutions for assays should be determined by the user.

Immunohistochemistry (IHC) of anti-Amyloid Fibrils (OC) antibody

Immunohistochemistry analysis using Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507). Tissue: Alzheimer's Disease brain. Species: Human. Fixation: Formalin fixed. Primary Antibody: Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507) at 1:5000. Secondary Antibody: Goat Anti-Rabbit ATTO 488 (green). Localization: Plaque. (A) Amyloid Fibril (OC) Antibody (SPC-507). (B) Amyloid Oligomer (A11) Antibody (SPC-506). (C) Composite. Courtesy of: Dr. Elizabeth Head, University of California, Irvine.
Rabbit Anti-Amyloid Fibrils (Oc) Polyclonal Antibody – Cat# MBS805797

Immunohistochemistry (IHC) of anti-Amyloid Fibrils (OC) antibody

Immunohistochemistry analysis using Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507). Tissue: Alzheimer's Disease brain. Species: Human. Primary Antibody: Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507) at 1:100. Extensive OC labeling was observed in the hippocampus (A), subiculum (B) and frontal cortex (C) in Alzheimer disease. A higher magnification image illustrates that OC positive deposits were dense and consisted of fine fibrillar material (D). Courtesy of: Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., et al. (2003). Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486-489. doi: 10.1126/science.1079469.
Rabbit Anti-Amyloid Fibrils (Oc) Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS805797

Western Blot (WB) of anti-Amyloid Fibrils (OC) antibody

Western blot analysis of Human Abeta42 fibrils and prefibrillar oligomers showing detection of Amyloid Fibrils (OC) protein using Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507). Primary Antibody: Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507) at 1:1000. Courtesy of: Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., et al. (2003). Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486-489. doi: 10.1126/science.1079469.
Rabbit Anti-Amyloid Fibrils (Oc) Polyclonal Antibody, Western Blot (WB) – Cat# MBS805797

Immunohistochemistry (IHC) of anti-Amyloid Fibrils (OC) antibody

Immunohistochemistry analysis using Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507). Tissue: Alzheimer's Disease brain. Species: Human. Primary Antibody: Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507) at 1:100. Showing no Amyloid Precursor Protein (APP) cross-reactivity (L), but when conducted with monoclonal 6E10 (R) shows considerable APP cross-reactivity. Courtesy of: Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., et al. (2003). Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486-489. doi: 10.1126/science.1079469.
Rabbit Anti-Amyloid Fibrils (Oc) Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS805797

Dot Blot (DB) of anti-Amyloid Fibrils (OC) antibody

Dot blot analysis using Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507). Tissue: Abeta42 fibrils and prefibrillar oligomers. Species: Human. Primary Antibody: Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507) at 1:1000. Courtesy of: Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., et al. (2003). Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486-489. doi: 10.1126/science.1079469.
Rabbit Anti-Amyloid Fibrils (Oc) Polyclonal Antibody, Dot Blot (DB) – Cat# MBS805797

Dot Blot (DB) of anti-Amyloid Fibrils (OC) antibody

Dot blot analysis using Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507). Tissue: Cell lysates. Species: Human. Primary Antibody: Rabbit Anti-Amyloid Fibrils (OC) Polyclonal Antibody (SPC-507) at 1:500, 1:5000. Beta Amyloid HEPES-NaCl aggregation, showing 1:500 (L) and 1:5000 (R) time lapse dot blot.
Rabbit Anti-Amyloid Fibrils (Oc) Polyclonal Antibody, Dot Blot (DB) – Cat# MBS805797

Product References and Citations for anti-Amyloid Fibrils (OC) antibody

1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547. 2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366. 3. Kayed R., et al. (2003) Science. 300(5618): 486-489.

Other Notes

Small volumes of anti-Amyloid Fibrils (OC) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Amyloid Fibrils (OC) purchase

MBS805797 is an antibody targeting Amyloid Fibrils (OC). Also known as Amyloid Fibrils (OC) Antibody: Biotin
Rabbit Anti-Human Amyloid Fibrils (OC) Antibody Polyclonal. Reactive in Human. Host: Rabbit.
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