HSPB2 Antibody – Rabbit Polyclonal

Background Info: Detects ~27kDa

Scientific Background: HSPB2, also known as MKBP is the most divergent member of the sHSP family with only 30% sequence identity to all other mammalian sHSPS (1). MKBP is known to associate specifically with myotonic dystrophy protein kinase (DMPK) in skeletal muscle. MKBP enhances the kinase activity of DMPK and protects it from heat-induced activation. MKBP also shows a unique nature compared to other sHSps, in that the expression of MKBP is not induced by heat shock (2). In unstressed skeletal muscle, MKBP forms large oligomeric complexes with HSPB3 in the cytosol which are localized on mitochondria and the neuromuscular junction (1, 3). During stress, these complexes dissolve and MKBP's localization to mitochondria increases, leading to increased cell survival. Pinz et al. tried to find a distinct role for MKBP in terms of cardiac mechanics and finds that it is required for normal systolic performance and normal cardiac energetic (1). HSPB2 has also been found to be expressed in several cancer cell lines, including human breast cancer, suggesting that MKBP may be an important factor in tumor transformation and metastasis (4).

1. Pinz I., et al. (2008) FASEB J. 22: 84-92. 2. Suzuki A., et al. (1998) J Cell Bio. 140(5): 1113-1124. 3. Sugiyama Y., et al. (2000) J Biol Chem. 275: 1095-1104. 4. Oshita S.E., et al. (2010) Breast Cancer Res Treat. Epub: 20087649.

Small volumes of anti-HSPB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS806238 is an antibody targeting HSPB2. Also known as HSPB2 (MKBP) Antibody: ATTO 594. Reactive in Human, Mouse, Rat. Host: Rabbit.