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Hsp110 (HSPH1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS806244

Background Info: Detects ~110kDaScientific Background: Hsp110 belongs to a family of large stress proteins known as the Hsp110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied Hsp70 family. They share 30-33%… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
Hsp110 (HSPH1), Polyclonal Antibody
Full Product Name
Hsp110 Antibody
Product Gene Name
anti-HSPH1 antibody
Product Synonym Names
Heat shock 105kDa alpha; heat shock 105kDa beta; Hsp105; Hsp105A; Hsp105B; Hsp110; HSPH1; NY CO 25
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Monkey, Hamster, Rat, Mouse, Cow, Sheep, Yeast
Form/Format
Affinity Purified
Concentration
1mg/mL (lot specific)
Preparation and Storage
-20 degree C
Molecular Weight
97,460 Da
OMIM
610703
3D Structure
ModBase 3D Structure for Q92598
Certificate of Analysis
1 ug/mL of SPC-195 was sufficient for detection of Hsp110 in 10ug of human cell line mixed lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Storage Buffer
PBS pH7.2, 50% glycerol, 0.09% sodium azide

Product Categories/Family for anti-HSPH1 antibody

Chaperones; Heat Shock
Applications Tested/Suitable for anti-HSPH1 antibody
Western Blot (WB)
Application Notes for anti-HSPH1 antibody
1:1000 (WB)

Immunohistochemistry (IHC) of anti-HSPH1 antibody

Immunohistochemistry analysis using Rabbit Anti-HSP110 Polyclonal Antibody (SPC-195). Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative Solution. Primary Antibody: Rabbit Anti-HSP110 Polyclonal Antibody (SPC-195) at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:50 for 1 hour at RT. Localization: Positive epidermal, dermal and muscle staining.
Rabbit Anti-HSPH1 Polyclonal Antibody – Cat# MBS806244

Western Blot (WB) of anti-HSPH1 antibody

Western blot analysis of Human Cell line lysates showing detection of HSP110 protein using Rabbit Anti-HSP110 Polyclonal Antibody (SPC-195). Load: 15 ugprotein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Rabbit Anti-HSP110 Polyclonal Antibody (SPC-195) at 1:1000 for 2 hours at RT. Secondary Antibody: Donkey Anti-Rabbit IgG: HRP for 1 hour at RT.
Rabbit Anti-HSPH1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS806244

Product References and Citations for anti-HSPH1 antibody

1. Lee-Yoon D., et al. (1995) J Biol Chem. 270: 15725-15733. 2. Dragovic Z., et al. (2006) EMBO J. 25: 2519- 2528. 3. Nakamura J., et al. (2008) Stroke. 39(10): 2853-2859. 4. Subject D.R. (2001) Health Research Inc. Report number AS90893: 1-84.

Other Notes

Small volumes of anti-HSPH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSPH1 purchase

MBS806244 is an antibody targeting HSPH1. Also known as Hsp110 Antibody. Reactive in Human, Monkey, Hamster, Rat, Mouse, Cow, Sheep, Yeast. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSPH1. It may not necessarily be applicable to this product.

NCBI GI #
42544159
NCBI GeneID
10808
NCBI Accession #
NP_006635.2
UniProt Primary Accession #
Q92598
UniProt Secondary Accession #
O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q9UPC4; B4DYH1
UniProt Related Accession #
Q92598
GenBank Nucleotide #
NM_006644.3
NCBI Official Full Name
heat shock protein 105 kDa isoform 1
NCBI Official Synonym Full Names
heat shock 105kDa/110kDa protein 1
NCBI Official Symbol
HSPH1
NCBI Official Synonym Symbols
HSP105; HSP105A; HSP105B; NY-CO-25
UniProt Protein Name
Heat shock protein 105 kDa
UniProt Synonym Protein Names
Antigen NY-CO-25; Heat shock 110 kDa protein
Protein Family
Heat shock protein
UniProt Gene Name
HSPH1
UniProt Synonym Gene Names
HSP105; HSP110; KIAA0201
UniProt Entry Name
HS105_HUMAN
NCBI Protein Information
heat shock protein 105 kDa; antigen NY-CO-25; heat shock 105kD beta; heat shock 105kD alpha

UniProt Comments for HSPH1

HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.

Protein type: Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol

Molecular Function: protein binding; ATP binding; alpha-tubulin binding

Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein
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Research Articles on HSPH1

1. A receiver operating characteristic curve constructed with HSP105 and TIM gave a sensitivity of 54.3% and 95% (38/40) specificity in discriminating esophageal squamous cell carcinoma from matched controls.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HSPH1 antibody

 Reference Product  PubMed Publications
 DNAJB1 antibody  >8 publications with HSPH1 and DNAJB1
 DNAJA1 antibody  >5 publications with HSPH1 and DNAJA1
 HSPA8 antibody  >4 publications with HSPH1 and HSPA8
 HSP90AA1 antibody  >1 publications with HSPH1 and HSP90AA1

Pathways associated with anti-HSPH1 antibody

 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Scavenging By Class F Receptors Pathway antibodies  Scavenging By Class F Receptors Pathway Diagram

Diseases associated with anti-HSPH1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >6 publications with HSPH1 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >3 publications with HSPH1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >3 publications with HSPH1 and Disease Models, Animal
 Inflammation Antibodies  >3 publications with HSPH1 and Inflammation
 Heart Diseases Antibodies  >2 publications with HSPH1 and Heart Diseases
 Nervous System Diseases Antibodies  >2 publications with HSPH1 and Nervous System Diseases
 Pancreatic Neoplasms Antibodies  >2 publications with HSPH1 and Pancreatic Neoplasms
 Necrosis Antibodies  >2 publications with HSPH1 and Necrosis
 Neoplasms, Experimental Antibodies  >1 publications with HSPH1 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >1 publications with HSPH1 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-HSPH1 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >7 publications with HSPH1 and Skin
 Blood Antibodies  >7 publications with HSPH1 and Blood
 Brain Antibodies  >7 publications with HSPH1 and Brain
 Lymph Node Antibodies  >3 publications with HSPH1 and Lymph Node
 Lymph Antibodies  >3 publications with HSPH1 and Lymph
 Testis Antibodies  >3 publications with HSPH1 and Testis
 Liver Antibodies  >2 publications with HSPH1 and Liver
 Intestine Antibodies  >2 publications with HSPH1 and Intestine
 Lung Antibodies  >2 publications with HSPH1 and Lung
 Vascular Antibodies  >2 publications with HSPH1 and Vascular
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